Bioabsorbable Vascular Patch with Oriented Filaments
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Solution Overview
Problem
Current treatments for aortic dissections and vascular damage primarily focus on mechanical repair rather than regeneration, leading to incomplete recovery of vascular function and high re-intervention rates, with existing stents not fully conforming to the aorta and causing further damage.
Innovation Solution
A vascular repair patch with a polymeric substrate featuring parallel and randomly oriented polymer filaments, designed for minimally-invasive endovascular deployment, promotes endothelial cell migration and smooth muscle cell integration, mimicking the structure and function of a healthy vascular wall, and is bioabsorbable to support complete repair and restoration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mechanical repair with existing stents is used, then structural support is provided, but complete vascular function recovery is not achieved and re-intervention rates remain high
Solution Approach 1:
The patent changes the fundamental parameter of the repair approach from mechanical support only to a combined mechanical-regenerative system. The patch incorporates growth factors and cellular components that actively promote tissue regeneration, transforming the static mechanical support into a dynamic healing environment that restores complete vascular function and reduces re-intervention needs
Solution Approach 2:
The invention uses a composite structure combining biocompatible polymer materials with biological active components (growth factors, cellular elements). This composite approach integrates mechanical integrity with regenerative capability, allowing the patch to provide both structural support and promote complete vascular function recovery, thereby reducing re-intervention rates
2Strength
If stents are deployed to provide structural support, then mechanical repair is achieved, but the stents do not fully conform to the aorta and cause further damage
Solution Approach 1:
The patent employs a flexible thin film patch structure that can conform to the complex geometry of the aortic wall. Unlike rigid stents, this flexible membrane adapts to the vessel's natural contours, providing structural support while minimizing mechanical damage to the vessel wall and eliminating the conformance problems associated with traditional stent deployment
3Strength
If permanent non-bioabsorbable materials are used for repair, then immediate structural integrity is provided, but complete vascular regeneration is inhibited
Solution Approach 1:
The patent changes the temporal parameter of the repair material from permanent to temporary (bioabsorbable). The patch is designed with controlled degradation characteristics that match the tissue regeneration timeline, providing structural support during the critical healing phase and then gradually being absorbed as native tissue matures, thereby enabling complete vascular regeneration without permanent foreign material
Solution Approach 2:
The invention implements a temporary support strategy where the bioabsorbable patch provides necessary structural integrity during the regeneration process and is then naturally discarded as the body's own vascular tissue takes over. This approach allows complete vascular regeneration by removing the permanent barrier that non-bioabsorbable materials create, enabling full tissue remodeling and function restoration
Data Source
AI summary
A vascular repair patch comprises a polymeric substrate having first and second major surfaces, and at least first and second polymer filament layers, wherein the polymer filaments of the first polymer filament layer are oriented in parallel and the polymer filaments of the second polymer filament layer are oriented randomly. The patch may further include thrombogenic agents and/or extracellular matrix compounds to promote vascular tissue regeneration at the repair site. Further, included are methods of making and using the patch.