Vascular Pressure Difference Calculation via CT Morphology and Fluid Dynamics
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Solution Overview
Problem
Existing methods for measuring fractional flow reserve (FFR) in coronary arteries, such as using pressure guide wires, are invasive, costly, and can cause discomfort to patients, while also being prone to errors due to variations in lesion location, size, and type, as well as individual physiological differences.
Innovation Solution
A method and device for obtaining vascular pressure difference that incorporates anatomical and individual data to create a geometric model and blood flow model of the target blood vessel, allowing for the calculation of pressure difference using a morphological difference function that considers plaque information and blood flow velocity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If pressure guide wire is used to measure FFR value, then measurement precision of coronary stenosis function is improved, but device complexity and ease of operation deteriorate
Solution Approach 1:
The patent uses CT imaging to create a virtual copy of the coronary artery anatomy and applies computational fluid dynamics to simulate blood flow, replacing the physical pressure guide wire with a digital model that replicates the measurement function without requiring invasive insertion
Solution Approach 2:
The patent replaces the mechanical pressure guide wire system with a computational system that uses CT anatomical data and fluid dynamics equations to calculate FFR values, substituting physical measurement with mathematical simulation
2Measurement precision
If pressure guide wire is used to measure FFR value, then measurement precision of coronary stenosis function is improved, but ease of operation deteriorates
Solution Approach 1:
The patent creates a virtual replica of the coronary artery using CT imaging and computational models, allowing FFR measurement to be performed on the digital copy without requiring the operator to manually navigate a physical guide wire through the patient's vasculature
Solution Approach 2:
The patent replaces the manual mechanical operation of inserting and positioning a pressure guide wire with an automated computational process that calculates FFR values based on CT anatomical data and fluid dynamics simulations
3Reliability
If pressure guide wire is used to measure FFR value, then reliability of diagnosis is improved, but object-affected harmful factors increase
Solution Approach 1:
The patent uses CT imaging to create a detailed virtual copy of the coronary artery anatomy, allowing diagnostic measurements to be performed on the digital model without requiring physical insertion of a guide wire that could damage the patient's blood vessels
Solution Approach 2:
The patent replaces the invasive mechanical measurement system with a non-invasive computational approach that uses CT anatomical data and fluid dynamics equations to determine FFR values, eliminating the need for physical contact with the patient's vasculature
4Measurement precision
If pressure guide wire is used to measure FFR value, then measurement precision is improved, but loss of substance increases
Solution Approach 1:
The patent replaces the pharmacological method of inducing hyperemia with a computational approach that uses fluid dynamics equations to simulate maximum blood flow conditions, eliminating the need to administer adenosine, ATP, or other vasodilator drugs to the patient
Solution Approach 2:
The patent creates a computational model that replicates the physiological effect of maximum hyperemia through mathematical simulation, allowing FFR measurement without requiring actual drug-induced vasodilation in the patient's coronary arteries
5Ease of operation
If conventional medical testing methods such as coronary angiography and CT are used, then ease of operation is improved, but measurement precision of coronary ischemia deteriorates
Solution Approach 1:
The patent merges conventional CT angiography, which provides easy-to-obtain anatomical data, with computational fluid dynamics modeling, which provides precise functional assessment, creating a hybrid approach that maintains the ease of data acquisition while achieving accurate ischemia evaluation
Solution Approach 2:
The patent introduces computational fluid dynamics simulation as an intermediary process that bridges the gap between conventional CT anatomical imaging and precise functional assessment of coronary ischemia, using the CT data as input to generate accurate FFR values
Data Source
AI summary
The present invention provides a method and device for obtaining the pressure difference of blood vessels. The method for obtaining the pressure difference of a blood vessel includes: receiving anatomical data of a part of a blood vessel segment, obtaining a geometric model of a target blood vessel according to the anatomical data; obtaining a blood flow model of the target blood vessel and the target blood vessel according to the anatomical data and combining individual data The blood flow velocity V; the geometric model is preprocessed, the cross-sectional morphological model is established, and the shape difference function f(x) of the target blood vessel lumen is calculated, based on the shape difference function f(x) of the target blood vessel lumen And the blood flow velocity V, the pressure difference value ΔP at any two positions of the target blood vessel is calculated. The method for obtaining vascular pressure difference provided by the present invention introduces the concept of morphology to clarify the influence of vascular morphology on the calculation of vascular pressure difference and improve the accuracy of calculation of vascular pressure difference.