Bioremodelable Vascular Prostheses Using ECM and PGS Infusion
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Solution Overview
Problem
Conventional tissue prostheses often cause harsh biological responses, intimal hyperplasia, and mechanical incompatibility, leading to complications such as inflammation, infection, and the need for additional surgical procedures to remove them, due to their non-biodegradable and irritating nature.
Innovation Solution
Development of bioremodelable vascular casted constructs using ECM materials derived from mammalian tissues, infused with biomaterial compositions like poly(glycerol sebacate) and biologically active agents, which are designed to promote tissue regeneration and reduce inflammatory responses, and can be reinforced with external structures for enhanced mechanical properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional non-biodegradable prosthetic materials are used, then mechanical strength and structural stability are maintained, but harsh biological responses, inflammation, and intimal hyperplasia occur
Solution Approach 1:
The patent changes the material parameter from non-biodegradable to biodegradable, specifically using poly(glycerol sebacate) with controlled degradation rates. This allows the prosthesis to maintain structural stability during the critical healing period while gradually degrading to eliminate long-term foreign body responses and inflammation
Solution Approach 2:
The patent employs composite material construction by infusing the ECM scaffold with biodegradable polymer materials like poly(glycerol sebacate). This composite approach combines the biological compatibility of ECM with the mechanical strength of synthetic biodegradable polymers, achieving both structural stability and reduced biological harm
2Object-affected harmful factors
If bioabsorbable and biodegradable materials are used, then biological compatibility is improved, but the materials break down at a faster rate than desirable and form large rigid fragments
Solution Approach 1:
The patent modifies the degradation parameter by selecting poly(glycerol sebacate) with specific molecular weight and crosslinking density, achieving a degradation rate that matches the tissue regeneration timeline. The material maintains structural integrity for the required duration before gradually breaking down into manageable byproducts
Solution Approach 2:
The patent applies different material properties to different regions of the prosthesis structure. The ECM scaffold provides initial structural support while the infused biodegradable polymer maintains mechanical strength, with each component degrading at appropriate rates to prevent fragment formation
3Ease of manufacture
If conventional polymeric prostheses are used, then ease of manufacture is improved, but irritation and undesirable biologic responses occur requiring additional surgical procedures
Solution Approach 1:
The patent changes the chemical composition parameter from conventional polymers to biodegradable polymers like poly(glycerol sebacate), which inherently reduce irritation and biologic responses. This material substitution maintains ease of manufacture through established polymer processing techniques while eliminating the need for removal surgery
Data Source
AI summary
Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.