Vascularity Affinity Scaffold for AVN Bone Revascularization
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Solution Overview
Problem
Current treatments for avascular necrosis (AVN) and musculo-skeletal tissue injuries fail to provide a comprehensive environment for bone healing and regeneration, relying only on partial solutions that do not address disease progression or promote vascularization, angiogenesis, and bone repair.
Innovation Solution
A medical device comprising osteogenic cells, osteoconductive scaffolds, growth factors, and a stable mechanical environment, delivered through a Vascularity Affinity Precursor Structure (VAPS) that includes Bone Marrow Aspirate, Platelet-Rich Plasma, and biomimetic calcium phosphate, to facilitate vascularization, angiogenesis, and bone repair.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If current surgical treatments (core decompression, osteotomy, bone graft, arthroplasty) are used to treat AVN, then pain relief is achieved through removal of dead bone, but the treatments do not address disease progression or provide bone healing and repair at the diseased site
Solution Approach 1:
The device performs preliminary action by delivering osteogenic cells, growth factors, and osteoconductive scaffolds to the AVN site before complete bone collapse occurs. This proactive approach aims to stimulate bone regeneration and vascularization early in the disease process, preventing progression to the point where only palliative pain relief is possible
Solution Approach 2:
The device acts as an intermediary by introducing external biological agents (osteogenic cells from bone marrow aspirate, growth factors from platelet-rich plasma, and osteoconductive scaffolds) that mediate the healing process between the damaged bone and the body's natural repair mechanisms, bridging the gap where natural healing is insufficient
2Object-affected harmful factors
If non-surgical treatments (medication, reduced weight bearing, electrical stimulation) are used to treat AVN, then temporary pain relief is achieved, but the relief is only short term and surgical intervention is ultimately required
Solution Approach 1:
The device changes the fundamental parameters of bone healing by introducing concentrated osteogenic cells, growth factors, and structural scaffolds that transform the biological environment at the AVN site. This shifts the treatment from temporary symptomatic management to active regeneration, potentially changing the disease course from progressive degradation to reparative regeneration
Solution Approach 2:
The device employs composite materials combining osteogenic cells, growth factors, and osteoconductive scaffolds in a single integrated system. This composite approach synergistically combines cellular, chemical, and structural elements to create a comprehensive regenerative environment that addresses multiple aspects of bone healing simultaneously
3Reliability
If a comprehensive device delivering osteogenic cells, growth factors, and osteoconductive scaffolds is used, then bone healing and regeneration is promoted, but the device complexity increases
Solution Approach 1:
The device merges multiple therapeutic components (osteogenic cells from bone marrow aspirate, growth factors from platelet-rich plasma, and osteoconductive scaffolds) into a single integrated delivery system. This consolidation simplifies the clinical workflow by combining steps that would otherwise require separate procedures, while maintaining the comprehensive regenerative capability
Solution Approach 2:
The device achieves multi-functionality by simultaneously providing cellular therapy (osteogenic cells), biochemical stimulation (growth factors), and structural support (osteoconductive scaffolds). This universal approach addresses multiple aspects of bone regeneration in a single intervention, reducing the need for multiple separate treatments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enhances bone repair and regeneration by delivering all necessary components simultaneously, reducing the need for invasive surgeries and preventing disease progression, thereby improving patient recovery and reducing morbidity.
Implementation Method 1
an osteoconductive scaffold which provides a stable mechanical environment
Implementation Method 2
A first component comprising a biological material configured to carry and maintain growth factors
Implementation Method 3
A second component comprising a biological material configured to carry and maintain viable osteogenic and/or angiogenic cells
Implementation Method 4
Injured bone, which may be necrotic and insufficiently vascularized... it is imperative to provide the body with an environment rich in angiogenic factors
Implementation Method 5
it is imperative to provide the body with an environment rich in angiogenic factors, (typically, through the provision of hematopoietic stem cells and endothelial progenitor cells)
Data Source
AI summary
The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and/or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.