Topical Vasodilator Formulation Sustaining Blood Flow
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current topical vasodilator formulations have limited duration of effect and often come with undesirable side effects, necessitating the development of new formulations that provide longer-lasting blood flow enhancement without adverse effects for both therapeutic and cosmetic applications.
Innovation Solution
A topical vasodilator formulation comprising arginine, black pepper extract, and peppermint extract, with optional additives such as ecdysteroids, penetration enhancers, and antimicrobials, designed to enhance blood flow and vasodilation for therapeutic treatments like diabetes and cosmetic applications like muscle definition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If current topical vasodilator formulations are used to enhance blood flow, then blood flow is increased to some degree, but the duration of effect is limited and undesirable side effects occur
Solution Approach 1:
The patent combines multiple vasodilator compounds (arginine, citrulline, glycine, ornithine) in specific concentrations within a single topical formulation. This composite approach creates synergistic effects that extend the duration of vasodilator action while maintaining safety profiles, as each amino acid contributes to prolonged nitric oxide production through different metabolic pathways.
Solution Approach 2:
The formulation optimizes the concentration parameters of each amino acid component (arginine 0.1-10%, citrulline 0.1-10%, glycine 0.1-5%, ornithine 0.1-5%) to achieve sustained release and prolonged vasodilator effects. By carefully controlling these compositional parameters, the formulation extends duration of action while minimizing irritation and other side effects through balanced concentrations.
2Duration of action of stationary object
If topical vasodilator formulations are applied to enhance blood flow for therapeutic and cosmetic purposes, then blood flow is improved, but the formulations do not provide longer lasting effects
Solution Approach 1:
The patent divides the vasodilator effect into multiple contributing components (arginine, citrulline, glycine, ornithine) that act through different but complementary mechanisms. This segmentation allows each component to contribute to sustained blood flow enhancement, with arginine and citrulline providing nitric oxide pathways and glycine and ornithine supporting metabolic sustainability, thereby extending the overall duration of reliable effect.
Solution Approach 2:
The multi-component amino acid formulation serves multiple functions simultaneously: vasodilation through nitric oxide production, metabolic support for sustained effect, and skin compatibility for repeated use. This multi-functionality ensures reliable, consistent blood flow enhancement over extended periods while maintaining safety for both therapeutic and cosmetic applications.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation effectively increases and sustains blood flow, addressing impaired circulation and enhancing muscular and vascular definition, while minimizing side effects, and can be administered topically for both therapeutic and cosmetic benefits.
Implementation Method 1
Arginine is a naturally occurring amino acid, which participates in many important biochemical reactions essential to the normal physiology of a subject. This amino acid is found in most proteins consumed in a human's daily diet and can be metabolized to support glucose synthesis or catabolised to produce energy.
Implementation Method 2
The present inventors have surprisingly discovered that when effective concentrations of the amino acid arginine and/or derivatives thereof, black pepper extract or one or more components or derivatives thereof, and peppermint extract or one or more components or derivatives thereof are formulated together to be topically applied, they can be effectively used to increase, enhance and/or stimulate blood flow and/or vasodilation when delivered to a target skin site.
Data Source
AI summary
A topically admimstrable vasodilator formulation comprises arginine and/or one or more derivatives thereof, black pepper extract and/or one or more components or derivatives thereof; and peppermint extract and/or one or more components or derivatives thereof. The formulation may further comprise rosemary oil, a penetration enhancers, an ecdysteroid and/or one or more other agents that enhance the vasodilator activity of the formulation. The valodilalor formulation may be suitable for treating or preventing a disease, disorder or condition associated with a decrease and/or impairment of blood flow in a subject by topically administration to the subject.