VE-cadherin Expression Promoting Agent for Capillary Stabilization
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Solution Overview
Problem
The decrease in the number of capillaries with age leads to various health and cosmetic issues due to reduced blood flow and mucus secretion, affecting organs and skin, resulting in conditions such as dry eye, hair loss, and skin sagging.
Innovation Solution
An expression promoting agent for adhesion molecules in vascular endothelial cells, specifically VE-cadherin and integrin α5, using yeast extract or plant extracts like Calendula officinalis, Siberian ginseng, and Cistanche salsa, which increases the expression of these molecules, stabilizing and enhancing capillary function and number.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If capillaries are used to supply blood to cells, then oxygen and nutrients are delivered to cells, but the number of capillaries decreases with age leading to reduced function
Solution Approach 1:
The patent changes the parameter of adhesion molecule expression levels in vascular endothelial cells by applying specific extracts (yeast extract, plant extracts), thereby improving capillary stabilization and function without requiring an increase in capillary number
Solution Approach 2:
The patent uses adhesion molecules (VE-cadherin, integrin α5) as intermediaries between vascular endothelial cells and the extracellular matrix to improve capillary function. These molecules mediate the interaction and stabilization of capillary structures
2Reliability
If adhesion molecules are increased to stabilize capillaries, then capillary function improves, but the complexity of the solution increases
Solution Approach 1:
The patent employs natural extracts (yeast extract, plant extracts) that self-regulate and promote adhesion molecule expression through biological pathways inherent to the system, rather than requiring complex external control mechanisms
Solution Approach 2:
The patent simplifies the solution by changing the parameter of substance composition (using specific natural extracts) rather than implementing complex structural or procedural changes to achieve capillary stabilization
Data Source
AI summary
The purpose of the present invention is to provide a substance related to the stabilization of capillary blood vessels. This invention is based on the discovery that an extract from a plant selected from the group consisting of Calendula officinalis, Siberian ginseng, and Cistanche salsa increases gene expression of VE-cadherin or integrin α5.