Ventricle Segmentation in Contrast-Enhanced Cine MRI

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Solution Overview

Problem

Current automatic segmentation methods for ventricles in contrast-enhanced cine MRI datasets face challenges due to increased signal intensity of infarcted myocardium, leading to decreased signal intensity differences with the blood-pool cavity, making accurate segmentation difficult.

Innovation Solution

The method utilizes additional MRI datasets, such as delayed-enhancement and first-pass perfusion datasets, acquired during the same imaging session to provide information that assists in segmenting the ventricle in contrast-enhanced cine MRI datasets by mapping features like infarct and blood-pool cavity information to refine the segmentation process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If contrast-enhanced cine MRI is performed after contrast administration, then time efficiency is improved and patient discomfort is reduced, but signal intensity difference between blood-pool cavity and myocardium decreases making segmentation more difficult

Engineering Contradiction:
Improvetime efficiencyVSAvoidsegmentation difficulty
Core Design Contradiction:
Loss of timeVSDifficulty of detecting and measuring

Solution Approach 1:

The patent applies segmentation by dividing the ventricle into distinct regions (endocardial border and epicardial border) and processing them separately through automated segmentation algorithms. This allows precise delineation of ventricular boundaries despite the reduced signal intensity contrast in contrast-enhanced images.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent uses an intermediary approach by incorporating additional image processing techniques and algorithms that act as mediators between the contrast-enhanced image data and the segmentation output. These intermediaries help recover boundary information that is lost due to reduced signal contrast.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If manual segmentation is performed to achieve accurate ventricle delineation, then segmentation accuracy is improved, but time consumption increases significantly

Engineering Contradiction:
Improvesegmentation accuracyVSAvoidtime consumption
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent implements self-service through automated segmentation algorithms that perform ventricle delineation without requiring manual intervention. The system uses deformable models and image processing techniques to automatically identify and segment ventricular boundaries, making the process self-sufficient while maintaining accuracy.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces the mechanical manual segmentation process with automated computational methods. Deformable models and image-based algorithms substitute for manual tracing, eliminating the need for clinician time while preserving segmentation accuracy through sophisticated image processing.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Productivity

If traditional automatic segmentation methods are used on contrast-enhanced cine MRI, then processing speed is improved, but segmentation accuracy deteriorates due to reduced signal intensity difference

Engineering Contradiction:
Improveprocessing speedVSAvoidsegmentation accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The patent applies dynamics through deformable models that can adapt and change shape dynamically during the segmentation process. These models evolve iteratively to conform to the actual ventricular boundaries, allowing the segmentation to adjust to the reduced signal contrast conditions while maintaining both speed and accuracy.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent utilizes parameter changes by modifying segmentation algorithm parameters specifically for contrast-enhanced images. This includes adjusting threshold values, contrast weights, and model parameters to account for the reduced signal intensity difference, enabling accurate segmentation while maintaining automated processing speed.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentEP3477324B1Improving left ventricle segmentation in contrast-enhanced cine MRI datasets
Publication Date: 2025.03.26 PIE MEDICAL IMAGING
  • EP3477324B1 patent drawingFigure 1
  • EP3477324B1 patent drawingFigure 2
  • EP3477324B1 patent drawingFigure 3

AI summary

A method for delineating a ventricle from MRI data relating to the heart of a patient, the method comprising: a) providing a contrast-enhanced cine MRI dataset; b) providing one or more additional MRI datasets; c) segmenting one or more features on the additional MRI dataset or datasets; d) mapping the segmented features to the contrast-enhanced cine MRI dataset; e) using the segmented features as mapped in step d) to assist segmentation of the ventricle on the contrast-enhanced cine MRI dataset. A corresponding device and computer program are also disclosed.