Vertical Magnetic Field Purification Apparatus
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Solution Overview
Problem
Existing magnetic separation methods for purifying biological substances using highly magnetized magnetic beads often result in the beads forming needle-like aggregates that can be suctioned along with the purification liquid, leading to reduced extraction and purification efficiency.
Innovation Solution
A purification apparatus and method that utilizes a magnetic unit to generate a magnetic field gradient, allowing magnetic particles of amorphous metal to be fixed to the inner bottom or side of a container, preventing them from being suctioned with the liquid, by orienting the magnetic field lines vertically or radially, and using a movable magnetic unit to separate and collect the particles effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If highly magnetized magnetic beads are used to shorten inspection time and improve collection capability, then magnetic collection speed is improved, but the magnetic beads form needle-like aggregates that can be suctioned together with purification liquid, causing loss of substance
Solution Approach 1:
The patent changes the orientation dimension of magnetic field application from horizontal to vertical. By arranging the magnetic unit below the container and applying magnetic field lines in the vertical direction, the aggregates form along the vertical axis rather than horizontally, preventing them from being suctioned with liquid that is removed from the top or sides.
Solution Approach 2:
The patent applies magnetic field in advance during the aggregation step to control the formation orientation of magnetic bead aggregates. By pre-establishing vertical magnetic field lines before the suction operation, the aggregates are predetermined to form in a orientation that prevents liquid entrapment and subsequent loss during purification liquid removal.
2Manufacturing precision
If magnetic field is applied to separate magnetic particles from liquid, then separation efficiency is improved, but needle-like aggregates form extending along magnetic field lines, enabling suction of magnetic particles with liquid
Solution Approach 1:
The patent inverts the conventional approach by applying magnetic field from below the container rather than from the sides, and orienting magnetic field lines vertically upward. This inversion causes aggregates to form vertically along the container bottom rather than horizontally, fundamentally changing the aggregate morphology from needle-like extensions that trap liquid to compact vertical structures that do not entrap liquid.
Solution Approach 2:
The patent changes the spatial parameters of magnetic field application - specifically the position (below container vs. side), direction (vertical vs. horizontal), and distribution pattern of magnetic field lines. These parameter changes transform the aggregate formation mechanism, preventing needle-like structures while maintaining effective separation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively prevents the suction of magnetic particles with the liquid, reducing residual liquid amounts and enhancing the efficiency of substance extraction and purification by ensuring the magnetic particles remain in the container, thus improving the collection process.
Implementation Method 1
a magnetic unit arranged on the bottom plate or below the bottom plate so as to face the bottom portion of the container... The magnetic unit fixes magnetic particles of an amorphous metal to an inner bottom portion or an inner wall of the container
Implementation Method 2
By relatively moving the magnetic unit and the container, a liquid in the container and magnetic particles of an amorphous metal contained in the liquid are separated from each other and/or the magnetic particles are collected to the outside of the liquid
Data Source
AI summary
A purification apparatus includes a holding unit including a bottom plate for supporting a bottom portion of a container to be mounted, and a magnetic unit arranged on the bottom plate or below the bottom plate so as to face the bottom portion of the container. The magnetic unit fixes magnetic particles of an amorphous metal to an inner bottom portion or an inner wall of the container so as to separate a liquid in the container and the magnetic particles contained in the liquid from each other and/or to collect the liquid while leaving the magnetic particles in the container.