Laboratory Vessel Pipe Part Sealing Tissue Sample Processing
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Solution Overview
Problem
Existing laboratory vessels face challenges in efficiently and quickly processing tissue samples due to interference from preservation agents and molecular sieves, which can clog equipment and lead to contamination risks during sample processing.
Innovation Solution
A laboratory vessel design featuring a closable pipe part that seals against the vessel and includes a pestle for separating the tissue sample from treatment agents, allowing for hermetic separation and easy removal of the sample without interference from preservation substances, facilitating automated processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If molecular sieves are used as treatment agents in the laboratory vessel, then tissue sample preservation is improved, but pipette tips clog and lysis buffers are excessively adsorbed
Solution Approach 1:
The laboratory vessel is divided into two separate compartments: a first compartment for treating the tissue sample with molecular sieves and a second compartment for subsequent processing. This segmentation allows the molecular sieves to remain in the first compartment without interfering with pipette operations in the second compartment, resolving the clogging issue while maintaining preservation effectiveness.
Solution Approach 2:
The molecular sieves are extracted from the main processing area and placed in a separate first compartment. This extraction removes the harmful adsorption effect from the processing pathway, preventing excessive adsorption of lysis buffers and clogging of pipette tips while preserving the tissue sample in the isolated compartment.
2Object-generated harmful factors
If treatment agents are removed from the laboratory vessel prior to further processing, then interference with downstream processing is reduced, but additional process steps are required and contamination risk increases
Solution Approach 1:
The vessel is segmented into a first compartment for treatment and a second compartment for processing, eliminating the need to remove treatment agents. The tissue sample can be transferred between compartments without removing molecular sieves, thus reducing processing time and contamination risk while preventing interference with downstream processing.
Solution Approach 2:
The separated compartment structure acts as an intermediary system that allows treatment agents to remain in place while enabling subsequent processing operations. The compartment wall serves as a barrier that prevents interaction between treatment agents and processing reagents, eliminating the need for agent removal.
3Adaptability or versatility
If tissue sample is removed from the laboratory vessel for further processing, then processing flexibility is improved, but contamination risk and additional process steps increase
Solution Approach 1:
The laboratory vessel is divided into a first compartment for treatment and a second compartment for processing. The tissue sample can be transferred between compartments through a controlled interface, maintaining containment and reducing contamination risk while enabling processing flexibility. The segmented structure allows the sample to remain in the vessel throughout processing.
4Reliability
If molecular sieve is used in sufficient dosage for effective adsorption, then preservation effect is improved, but clogging of pipette tips occurs
Solution Approach 1:
The laboratory vessel is divided into a first compartment containing molecular sieves and a second compartment for processing. This segmentation allows sufficient molecular sieve dosage for effective preservation without risking clogging during pipette operations in the second compartment, as the molecular sieves are isolated from the processing area.
Solution Approach 2:
The molecular sieves are extracted from the processing pathway and placed in a separate first compartment. This extraction allows use of sufficient dosage for effective preservation while preventing contact with pipette tips and other processing equipment, thereby eliminating clogging risks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design enables simple and quick separation of tissue samples from treatment agents, reducing contamination risks and clogging issues, thereby enhancing the efficiency of tissue sample processing and automation in laboratory procedures.
Implementation Method 1
the pipe part seals against the laboratory vessel with its outer circumference
Implementation Method 2
a pestle is mounted in the laboratory vessel, over which the pipe part can be placed sealingly with its inner circumference
Data Source
AI summary
The present disclosure, according to one embodiment, describes a laboratory vessel for storing and treating a tissue sample comprises a closable opening, and additionally comprises a pipe part which is insertable in the opening of the laboratory vessel, wherein in inserted position, the pipe part seals against the laboratory vessel with its outer circumference and is clampingly displaceable with respect to said laboratory vessel, wherein a pestle is mounted in the laboratory vessel, over which the pipe part can be placed sealingly with its inner circumference. The laboratory vessel also comprises one or more tissue sample treatment agents. The tissue sample and the treatment agents are separated by placing the pipe part over the pestle, which separates a treatment agent region from a sample region.