3D-X-Ray Vessel Registration for Functional Perfusion Mapping
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Solution Overview
Problem
Existing X-ray subtraction angiography methods struggle to provide detailed prognostic information about regions nourished by perfused blood vessels, such as sensory or motor functions, during thrombus retrieval procedures, limiting the assessment of treatment effectiveness.
Innovation Solution
A medical image processing apparatus that acquires and processes X-ray images to identify flow changed vessels, registers them with 3D medical image data, and estimates dominant areas corresponding to these vessels, generating superimposed images to highlight areas of altered blood flow and their functional significance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If X-ray subtraction angiography is used to obtain contrast images, then blood vessel perfusion can be visualized, but detailed prognostic information about the nourished regions (sensory or motor functions) cannot be determined
Solution Approach 1:
The patent merges X-ray subtraction angiography (providing blood vessel perfusion information) with CT imaging (providing anatomical and functional region information) into a fused image. This combination allows simultaneous visualization of blood flow changes and the functional regions they nourish, thereby recovering the prognostic information that was lost when using only X-ray subtraction angiography.
Solution Approach 2:
The patent introduces a fusion image as an intermediary that bridges the gap between X-ray subtraction angiography and CT imaging. This fusion image serves as a mediator that integrates information from both modalities, allowing clinicians to assess both blood vessel perfusion and the functional significance of nourished regions in a single comprehensive visualization.
2Ease of operation
If only contrast images are used for thrombus retrieval procedure assessment, then blood flow amount and approximate location can be determined, but detailed functional prognosis information is unavailable
Solution Approach 1:
The patent combines the ease of blood flow assessment from contrast images with the functional region information from CT images by creating a fusion image. This merged visualization maintains the operational simplicity of assessing blood flow while simultaneously providing detailed functional prognosis information about the nourished regions, eliminating the need to switch between multiple imaging modalities.
3Measurement precision
If X-ray images alone are used, then blood vessel perfusion can be observed, but the functional significance of the nourished regions cannot be assessed
Solution Approach 1:
The patent merges X-ray imaging (providing precise blood vessel perfusion observation) with CT imaging (providing functional region identification) into a single fusion image. This approach maintains the high measurement precision of X-ray imaging for blood vessel perfusion while simultaneously adding the functional significance information from CT, thereby eliminating the information loss that would occur with X-ray imaging alone.
Data Source
AI summary
According to one embodiment, a medical image processing apparatus includes processing circuitry. The processing circuitry acquires correspondence information, based on 3D medical image data of an object, that corresponds a blood vessel to information on a dominant area of the blood vessel in a region of the object. The processing circuitry acquires a plurality of X-ray images each including the blood vessel that are collected at different time phases on the object. The processing circuitry identifies, based on the plurality of X-ray images, a flow changed vessel in which blood flow has changed between the different time phases. The processing circuitry performs registration between the flow changed vessel and the 3D medical image data. The processing circuitry estimates information on the dominant area corresponding to the flow changed vessel based on registration results and the acquired correspondence information.