Vial Adapter Inline Dry Drug Module for Needleless Syringe
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Solution Overview
Problem
Existing medical devices with inline dry drug modules are cumbersome and require larger injection angles, making them difficult to handle and use effectively for parenteral administration of injection solutions.
Innovation Solution
A medical device with a vial adapter and an inline dry drug module that includes a dry drug storage component and a uniform carrier liquid distribution component, allowing for easy preparation of needleless syringes with injection solutions using a needleless syringe and a vial, either initially empty or pre-filled, facilitating efficient and complete usage of dry drug dosages.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If existing medical devices with inline dry drug modules are used, then dry drug storage is enabled, but the devices become cumbersome and require larger injection angles
Solution Approach 1:
The device is divided into separate functional components: a vial adapter portion and a syringe portion, with the dry drug module integrated into the vial adapter. This segmentation allows the injection mechanism to remain compact and maneuverable while the storage function is separated into the vial component, resolving the contradiction between storage capability and ease of operation.
2Quantity of substance
If carrier liquid is flowed through porous substrate to dissolve dry drug dosage, then injection solution is formed, but uniform contact between carrier liquid and dry drug storage component is challenging
Solution Approach 1:
The dry drug storage component features a porous substrate with varying pore distributions and a radially extending fin structure that creates localized flow channels. This local quality variation ensures uniform carrier liquid distribution across the dry drug dosage, enabling complete dissolution and preventing aggregation, thus resolving the contradiction between solution formation and uniform contact distribution.
3Duration of action of stationary object
If dry drug dosage is stored for extended shelf-life in dry state, then drug stability is improved, but reconstitution requires precise control of dissolution process
Solution Approach 1:
The porous substrate and fin structure are designed to automatically guide carrier liquid flow through the dry drug dosage, enabling self-dissolution without external intervention. The structure itself controls the dissolution process by directing liquid flow paths, eliminating the need for precise manual control while maintaining complete drug reconstitution, thus resolving the contradiction between extended shelf-life and dissolution control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a convenient, cost-effective method for preparing needleless syringes with injection solutions, particularly suitable for thermo-stable drugs like vaccines, ensuring efficient and safe administration without the need for refrigeration.
Implementation Method 1
flowing carrier liquid through a porous substrate to dissolve or entrain a dry drug dosage
Implementation Method 2
dissolving the glass and causing the substance to be carried by the liquid into a patient
Data Source
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AI summary
Medical devices including a vial adapter (32) with an inline dry drug module(33) for use with a vial (20), a needleless syringe (10) and a carrier liquid (26) for filling the needleless syringe with an injection solution for injection to a patient. The inline dry drug modules (33) include a dry drug storage component (57) for storing a dry drug dosage and a uniform carrier liquid distribution component (58) for promoting uniform contact of the dry drug storage component by the carrier liquid to form an injection solution from the dry drug dosage. The inline dry drug modules can include a discrete dry drug storage component and a discrete uniform carrier liquid distribution component or a dual purpose component for both drug storage and uniform carrier liquid distribution. The vial adapters can be provided in vented or non-vented versions.