Vibration Dropping Micro Drop Pill Preparation
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Solution Overview
Problem
Traditional micro drop pill preparation methods have limitations such as low drug-loading capacity, large matrix amounts, inaccurate dosing, and residual coolants, which do not meet modern pharmaceutical standards for efficiency and patient convenience.
Innovation Solution
A method involving heat melting of medicine and matrix, followed by vibration dropping and gas cooling to produce micro drop pills with a higher drug-loading capacity and smaller particle size, eliminating the need for residual coolants and simplifying the production process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional gravity-based dropping method is used, then the process is simple, but the production rate is low and particle size is large
Solution Approach 1:
The patent applies vibration to the dropping system to increase the dropping frequency from traditional low rates to high-speed production. The vibration mechanism enables rapid formation and release of droplets, significantly increasing production rate while maintaining process simplicity through the addition of a vibration source to the existing dropping apparatus.
2Ease of manufacture
If traditional coolant-based solidification is used, then the cooling effect is strong, but residual coolant remains and requires additional removal steps
Solution Approach 1:
The patent extracts and removes the coolant component from the traditional drop pill preparation process. By replacing coolant-based solidification with gas-phase cooling, the harmful residual coolant is completely eliminated, simplifying the manufacturing process by removing the additional coolant removal step while avoiding contamination issues.
Solution Approach 2:
The patent substitutes the liquid coolant-based solidification system with a gas-phase cooling system. This replacement eliminates the need for immiscible liquid coolants and their subsequent removal, simplifying the process while avoiding residual solvent problems.
3Length of moving object
If traditional dropping method is used, then the equipment is simple, but the particle size is large and cannot be made less than 2.5 mm
Solution Approach 1:
The patent uses vibration to control droplet formation and size reduction. The vibration frequency and amplitude are optimized to produce smaller droplets that solidify into micro drop pills with particle sizes less than 2.5 mm, achieving the desired size reduction without complex equipment modifications.
Solution Approach 2:
The patent changes the physical parameters of the dropping system, including vibration frequency, dropping height, and gas flow rate, to control and reduce particle size. By optimizing these parameters, the system produces micro drop pills with precise size control below 2.5 mm while maintaining equipment simplicity.
4Loss of time
If traditional drying methods are used, then the drying process is simple, but the drying time is prolonged and volatile components are lost
Solution Approach 1:
The patent changes the drying parameters by using low temperature and controlled gas flow. This approach reduces drying time significantly while preventing the evaporation of volatile oil components through optimized temperature and atmosphere control, avoiding the losses associated with traditional high-temperature drying.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly increases drug-loading capacity, reduces matrix amounts, and produces micro drop pills with precise dosing and improved handling, meeting modern pharmaceutical standards and patient needs.
Implementation Method 1
cooling the medicine drops with a cooling gas to obtain micro drop pills
Implementation Method 2
cooling the medicine drops with a cooling gas to obtain micro drop pills
Data Source
AI summary
The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.