Vitis vinifera Cell Composition for UVB Inflammation Control
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Solution Overview
Problem
Current cosmetic compositions do not effectively inhibit interleukin inflammation mediators IL-1α and IL-6 at the human skin level while modulating human Beta Defensin 2, nor do they address UVB-induced skin inflammation and premature aging effectively.
Innovation Solution
A cosmetic composition comprising dedifferentiated elicited Vitis vinifera cells enriched with a specific hexapeptide compound, dispersed in a cosmetically acceptable support, which inhibits IL-1α and IL-6 and modulates Beta Defensin 2, providing protection against UVB-induced inflammation and skin aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic compositions are used, then basic skin care functions are provided, but they fail to effectively inhibit interleukin inflammation mediators IL-1α and IL-6 while modulating Beta Defensin 2
Solution Approach 1:
The patent combines dedifferentiated Vitis vinifera cells with specific hexapeptide compounds (Acetyl hexapeptide-8 and/or Acetyl hexapeptide-3) to create a composite cosmetic composition. This composite approach enables simultaneous inhibition of IL-1α and IL-6 inflammation mediators while modulating Beta Defensin 2, achieving multiple skin benefits that conventional single-ingredient compositions cannot provide.
Solution Approach 2:
The invention merges two distinct active components: dedifferentiated Vitis vinifera cells (which inhibit inflammation mediators) and hexapeptide compounds (which modulate Beta Defensin 2). By combining these components in a single composition, the patent achieves synergistic effects that simultaneously address multiple skin concerns including inflammation, aging, and bacterial protection.
2Object-affected harmful factors
If UVB protection is provided by conventional means, then basic sun protection is achieved, but UVB-induced inflammatory processes and premature aging are not effectively prevented
Solution Approach 1:
The cosmetic composition applies preliminary anti-action by using dedifferentiated Vitis vinifera cells and hexapeptide compounds to pre-inhibit the inflammatory response pathways (IL-1α and IL-6) before UVB damage can fully develop. This preventive mechanism blocks the inflammatory cascade that leads to premature aging, providing protection that goes beyond basic sun blocking.
Solution Approach 2:
The patent converts the harmful inflammatory response to UVB radiation into a beneficial controlled modulation by using specific ingredients that target and regulate the inflammatory mediators. The hexapeptide compounds modulate Beta Defensin 2 in response to UVB exposure, transforming the potentially harmful inflammatory cascade into a controlled protective response.
3Reliability
If simple cosmetic compositions are used, then ease of manufacture is maintained, but synergistic effects for reducing UVB irradiation effects are not achieved
Solution Approach 1:
The dedifferentiated Vitis vinifera cells are prepared in advance through a standardized protocol involving cell culture, dedifferentiation, and enrichment with active compounds. This preliminary preparation creates a ready-to-use active ingredient that can be directly incorporated into cosmetic formulations, achieving synergistic UVB protection effects while maintaining reasonable manufacturing simplicity through process standardization.
Data Source
AI summary
Cosmetic composition comprising a cosmetic effective amount of at least dedifferentiated elicited Vitis vinifera cells homogeneously distributed in a cosmetic acceptable support, whereby the dedifferentiated elicited Vitis vinifera cells are enriched with at least acetyl hexapeptide-8, whereby the dry weight content of acetyl hexapeptide-8 in the dedifferentiated Vitis vinifera cells in a form free from free water is comprised between 0.1% and 8%.