Violet Light Photostimulation for Parkinson's Symptom Relief
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Solution Overview
Problem
Current treatments for Parkinson's disease primarily focus on alleviating symptoms through drug therapy, which can have side effects like visual hallucinations and motor symptom deterioration, with no fundamental cure available.
Innovation Solution
Irradiation of violet light at specific wavelengths and blinking frequencies to treat and prevent motor and non-motor symptoms of Parkinson's disease using a light irradiating apparatus.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If dopamine replacement therapy is used to treat Parkinson's disease, then motor symptoms are improved, but visual hallucinations and motor symptom deterioration occur as side effects
Solution Approach 1:
The patent replaces pharmacological treatment (chemical system) with light stimulation (optical system). Specifically, violet light at 40Hz blinking frequency is applied to the eyes to stimulate the intrinsically photosensitive retinal ganglion cells, which then transmit signals to the suprachiasmatic nucleus to regulate circadian rhythm and improve Parkinson's symptoms without the harmful side effects of dopamine replacement therapy
Solution Approach 2:
The patent introduces an intermediary mechanism - the intrinsically photosensitive retinal ganglion cells and the circadian rhythm system - to mediate the treatment effect. Instead of directly administering dopamine which causes side effects, the light stimulation acts through the circadian rhythm pathway to indirectly improve motor symptoms and reduce hallucinations
2Object-affected harmful factors
If antipsychotic medicine is used to improve visual hallucinations, then visual hallucinations are reduced, but motor symptoms deteriorate
Solution Approach 1:
The patent replaces antipsychotic medication (chemical system) with light stimulation (optical system) to treat visual hallucinations. By stimulating the circadian rhythm system through violet light, the treatment addresses the underlying cause of hallucinations without the motor-symptom-deteriorating side effects of antipsychotics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively reduces symptoms such as visual hallucinations, motor impairments, and non-motor issues by stimulating the brain with violet light, offering a non-pharmacological treatment option.
Implementation Method 1
irradiation of light of a specific wavelength, particularly violet light (rays in a region of 360 nm to 400 nm), at a blinking frequency improves symptoms that are attributable to Parkinson's disease
Data Source
AI summary
The present invention provides a method of treating Parkinson's disease by light stimulation in which light of a specific wavelength such as violet light is irradiated at a specific blinking frequency. The present invention, by irradiating light of a specific wavelength such as violet light to a living body, carries out treatment and/or prophylaxis of Parkinson's disease by improving or suppressing at least one symptom selected from a group of symptoms consisting of cognitive memory disorder, working memory disorder, dysphoria, anxiety, apathy, psychological symptoms (hallucination, visual hallucination, and auditory hallucination), impulse control disorder, orthostatic hypotension, urinary disorder, sexual dysfunction, digestive symptoms (drooling, swallowing, nausea, constipation), sleep disorder, pain, weight loss, olfactory abnormality, fatigue, and diaphoresis.