Virtual Control Sample Database for Flow Cytometer Quality

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Solution Overview

Problem

Current measurement apparatuses for cell analysis, particularly particle analyzers like flow cytometers, face challenges in maintaining measurement accuracy and reproducibility without commercially available control samples, especially for low-frequency test items.

Innovation Solution

A measurement apparatus with a measurement unit, display unit, and processing unit that allows users to set an evaluation criterion for quality control and display quality control results, enabling effective quality control even without commercially available control samples.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If control samples are prepared in each clinical laboratory for low-frequency test items, then quality control can be performed, but preparation time and working hours increase

Engineering Contradiction:
Improvequality control capabilityVSAvoidpreparation time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The system creates virtual control samples by storing measurement data from actual control samples in a database. These virtual control samples can be repeatedly used without physical preparation, eliminating the need to prepare new control samples for each test while maintaining quality control capability.

Inventive Principle:
Principle #26Copying

Solution Approach 2:

Measurement data from control samples is collected and stored in advance in the database. When quality control is needed, the system retrieves pre-stored data instead of requiring new sample preparation, thus performing the quality control function without current preparation time investment.

Inventive Principle:
Principle #10Preliminary action

2Ease of operation

If commercially available control samples are used, then quality control is simplified, but control samples are not available for low-frequency test items

Engineering Contradiction:
Improvequality control processVSAvoidapplicability to low-frequency tests
Core Design Contradiction:
Ease of operationVSAdaptability or versatility

Solution Approach 1:

The system provides a universal quality control solution that works for both high-frequency and low-frequency test items. By using a database of stored measurement data, the system can generate control standards for any test item regardless of testing frequency, making the quality control process universally applicable.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The database acts as an intermediary between physical control samples and quality control decision-making. Instead of requiring physical control samples for every test, the system uses stored measurement data from the database to evaluate current measurement results, enabling quality control for test items without commercially available control samples.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If control graphs are generated using external tools like Excel, then quality control analysis can be performed, but user expertise is required and operation complexity increases

Engineering Contradiction:
Improvequality control analysis accuracyVSAvoidoperation complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The measurement apparatus performs quality control analysis automatically using its own built-in processing unit and database. The system retrieves stored control data, compares current measurements against historical data, and determines whether quality control standards are met without requiring external tools or user intervention in the analysis process.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system merges the quality control database, data processing capabilities, and analysis functions into the measurement apparatus itself. This integration eliminates the need for separate external tools like Excel and combines measurement and quality control functions into a single unified system.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentEP3629002B1Measurement apparatus and quality control method
Publication Date: 2025.04.30 SYSMEX CORP
  • EP3629002B1 patent drawingFigure 1
  • EP3629002B1 patent drawingFigure 2
  • EP3629002B1 patent drawingFigure 3

AI summary

Disclosed is a measurement apparatus that includes: a measurement unit configured to measure a control sample for quality control; a display unit; and a processing unit configured to cause the display unit to display an input screen for setting an evaluation criterion used in the quality control, and, in the measurement apparatus, the processing unit causes the display unit to display a quality control result of a test item, based on the evaluation criterion and a measurement result of the control sample.