Virus Concentration Determination Using Cation-Exchange Matrix

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Solution Overview

Problem

Current methods for determining the primary yield of influenza virus propagation cultures are time-consuming, costly, and only provide semiquantitative results, making it difficult to assess virus concentration quickly enough to inform processing decisions.

Innovation Solution

A method using a cation-exchange matrix to bind and elute virus particles or antigens under low salt conditions, followed by UV absorbance detection, allowing for rapid determination of virus concentration in a sample without the need for extensive purification.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional methods (HA titer or SRID test) are used to determine virus concentration, then measurement accuracy is improved, but time consumption and cost increase significantly

Engineering Contradiction:
Improvevirus concentration measurement accuracyVSAvoidtime required for determination
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The invention extracts only the essential function of virus concentration determination from the complex traditional methods. By using a specific antibody that binds to influenza virus and detecting this binding through a simplified assay format, the method extracts the core measurement capability while eliminating time-consuming steps such as radial diffusion and multi-day incubation periods required by SRID tests.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention replaces the mechanical/diffusion-based SRID test system with an immunological binding assay system. Instead of relying on radial diffusion through agarose gel over two days, the method uses direct antibody-virus binding detection, substituting a slow physical diffusion process with a faster biochemical interaction that can be measured more rapidly.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If virus purification is performed before concentration determination, then measurement reliability is improved, but cost and time consumption increase

Engineering Contradiction:
Improvemeasurement reliabilityVSAvoidprocess complexity and cost
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The invention enables the determination method to work directly with crude virus propagation culture samples without requiring external purification services or steps. The antibody-based assay is designed to specifically recognize and bind to influenza virus particles even in the presence of other culture components, allowing the system to self-determine concentration in the native crude sample matrix.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The invention uses a disposable or single-use antibody reagent that can directly detect virus concentration in crude samples. Instead of investing in expensive purification equipment and processes, the method employs a simple, inexpensive antibody-based detection system that can be applied directly to crude cultures, eliminating the need for costly and complex purification infrastructure.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Productivity

If rapid determination method is used, then productivity is improved, but measurement precision may deteriorate

Engineering Contradiction:
Improvedetermination speedVSAvoidconcentration measurement accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The invention changes the detection parameters by using a specific antibody with high affinity and specificity for influenza virus. This parameter change allows rapid binding kinetics while maintaining accurate quantification. The assay is designed with optimized incubation times and detection conditions that preserve measurement precision despite the reduced time frame compared to traditional methods.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables rapid and quantitative assessment of virus concentration, enabling timely decisions on further processing and reducing costs by avoiding unnecessary purification steps.

Implementation Method 1

contacting a sample containing virus particles and/or virus antigens to a cation-exchange matrix under low salt conditions that allow binding of said virus particles and/or virus antigens to said cation-exchange matrix

Methodology Applied
Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

detecting the virus particles and/or virus antigens by measuring UV absorbance of the elution fractions

Methodology Applied
Scientific EffectUV absorbance: Absorption (EM radiation)

Data Source

PatentEP1977245B1Method for determining the concentration of virus particles/virus antigens
Publication Date: 2013.04.24 NOVARTIS VACCINES
  • EP1977245B1 patent drawingFigure 1

AI summary

The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination of the concentration of virus particles and/or virus antigens in a sample.