Viscous Composite Biomaterial for Myocardial Adhesion
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current biomaterials for treating myocardial infarction and heart failure are not sticky, causing complex surgery and stress concentration, have mismatched mechanical properties with myocardium, are not degradable, and require invasive implantation, leading to foreign body reactions and complications.
Innovation Solution
A biodegradable, bio-safe, conductive, and highly sticky flexible substrate/liquid electrolyte composite material with mechanical properties matching myocardium, which can be applied directly to the epicardium without fixation, degrading within 6 to 24 months, and is suitable for minimally invasive surgery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If traditional biomaterials are used for patching the myocardium, then the ventricular wall can be strengthened, but the materials are not sticky and require complex suturing procedures
Solution Approach 1:
The patent modifies the chemical and physical parameters of the biomaterial by incorporating adhesive functional groups and adjusting mechanical properties to match myocardium, enabling the material to be both strong and sticky without complex suturing
Solution Approach 2:
The patent uses composite biomaterials combining structural support components with adhesive components, creating a material that simultaneously provides mechanical strength and bonding capability to the myocardium
2Strength
If elastic biomaterials are used for patching, then the ventricular wall can be strengthened, but the mechanical properties mismatch with myocardium causing heartbeat disorder
Solution Approach 1:
The patent adjusts the mechanical parameters of the biomaterial including elasticity modulus, viscosity, and relaxation characteristics to closely match the physiological parameters of myocardium, enabling better mechanical compatibility and preventing heartbeat disorders
3Strength
If non-degradable biomaterials are used for patching, then the ventricular wall can be strengthened, but foreign body reactions occur from host tissue
Solution Approach 1:
The patent modifies the chemical composition and degradation parameters of the biomaterial to be biocompatible and gradually degradable, allowing the material to maintain strength while reducing foreign body reactions as it safely degrades in the host tissue
4Ease of operation
If invasive open-chest surgery is used for implantation, then the composite material can be applied to the epicardium, but surgical risk and complexity increase
Solution Approach 1:
The patent utilizes the adhesive properties of the composite material to enable minimally invasive application methods, where the material can be delivered and adhered to the epicardium through less invasive procedures rather than requiring open-chest surgery
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite material effectively strengthens the myocardium, reduces fibrosis, and improves heart function by matching mechanical properties, being easy to apply and non-toxic, while avoiding the need for invasive procedures and reducing surgical risks.
Implementation Method 1
the electric conductivity is between 0.01 and 10 S/m
Implementation Method 2
bonding strength with the surface of organ tissue is higher than 0.1 kPa
Implementation Method 3
the ratio of loss modulus to storage modulus of said material is 0.2 to 5 when tested at 37° C., oscillation frequency at 0.01 to 100 Hz, strain at 0.01 to 10
Data Source
AI summary
Disclosed is a flexible substrate/liquid electrolyte viscous composite material and preparation method therefor. The preparation method includes: adding a particular percentage by weight of a flexible substrate to a liquid electrolyte solution having a particular concentrate; fully stirring the solution at a particular temperature to dissolve and evenly disperse the substrate, so as to obtain a viscous liquid; and then standing the viscous liquid at a particular temperature for a particular period of time to obtain the material. The material has viscosity due to which the material can actively adhere to the surface of tissue of an organ, the mechanical property matching cardiac muscle, biocompatibility and security, and is used for treating acute and chronic myocardial infarction and heart failures, inhibiting the reconstruction, thinning, and fiberization of a ventricular wall, and improving the myocardial function. In addition, the material also features conductivity, in vivo degradability, and the like.