Viscous Cyanoacrylate Adhesives with Biodegradable Viscosity Modifiers
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Solution Overview
Problem
There is a need for an absorbable and biocompatible viscosity modifying agent for cyanoacrylate compositions that exhibits controlled viscosity and biodegradability, suitable for medical applications, while maintaining stability and shelf life.
Innovation Solution
A monomer composition comprising at least one α-cyanoacrylate monomer and an absorbable viscosity modifying agent with specific structural units, such as 1-butoxy-1-oxopropan-2-yl methacrylate (BLMA), which is biodegradable and provides controlled viscosity, is used to form an adhesive or sealant that is minimally toxic and stable.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If a thickening or viscosity modifying agent is added to reduce run-off, then the viscosity is controlled, but the agent may not be biodegradable or biocompatible
Solution Approach 1:
The patent changes the chemical parameters of the viscosity modifying agent by selecting specific polymers with particular functional groups (carboxyl, hydroxyl, amino) and molecular weight ranges. This allows the agent to provide viscosity control while simultaneously being biodegradable and biocompatible, resolving the contradiction between stability and biocompatibility.
Solution Approach 2:
The patent creates a composite system by combining the cyanoacrylate monomer with specific biodegradable polymers (polyacrylic acid, polyacrylamide, carboxymethyl cellulose) in defined weight ratios. This composite approach enables the formulation to achieve both viscosity control and biodegradability, as the biodegradable polymer matrix provides both thickening and biocompatibility functions.
2Strength
If a non-absorbable viscosity modifying agent is used, then the adhesive properties are improved, but the composition cannot be completely eliminated from the body
Solution Approach 1:
The patent modifies the parameters of the viscosity modifying agent by selecting polymers with specific functional groups and molecular weights that enable both adequate adhesive strength and complete biodegradation. The carboxyl, hydroxyl, and amino groups provide bonding capability while the biodegradable nature ensures complete elimination from the body.
Solution Approach 2:
The biodegradable polymer viscosity modifying agent serves dual functions: providing adhesive strength during the healing process and then naturally degrading and being eliminated from the body without surgical removal. The agent's own chemical structure enables both its useful function and its eventual self-elimination.
3Speed
If the monomeric form is used for application, then the adhesive cures quickly, but the composition may run before application is complete
Solution Approach 1:
The patent adjusts the viscosity parameters of the monomeric composition by incorporating biodegradable polymer thickening agents at optimized concentrations (0.1-10% weight). This modifies the flow characteristics to prevent running while preserving the rapid curing property of the cyanoacrylate monomer, as the polymer acts as a rheology modifier without significantly affecting the polymerization kinetics.
4Loss of substance
If the adhesive is made biodegradable, then it can be eliminated from the body, but the shelf life may be reduced
Solution Approach 1:
The patent applies local quality by making only the viscosity modifying agent biodegradable while keeping the cyanoacrylate monomer stable. The biodegradable polymer is incorporated in controlled amounts (0.1-10% weight) to provide degradation capability without compromising the overall stability and shelf life of the monomeric composition. The stable monomer phase maintains long-term storage stability while the biodegradable polymer phase provides eventual elimination capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of BLMA as a viscosity modifying agent in cyanoacrylate compositions results in an adhesive or sealant that is biodegradable, maintains stability, and has a controlled viscosity, making it suitable for medical applications with a shelf life of at least one year at standard temperatures.
Implementation Method 1
a thickening or viscosity modifying agent may be added to a monomeric α-cyanoacrylate composition
Implementation Method 2
When an α-cyanoacrylate composition is applied, it is usually applied in its monomeric form, and the resultant polymer creates the desired adhesive bond or sealant strength
Implementation Method 3
the resultant polymer also be biodegradable, so that the degradation products are completely eliminated from the human body as waste products
Data Source
AI summary
A polymerizable adhesive composition comprises at least one α-cyanoacrylate monomer and at least one absorbable viscosity modifying agent. The absorbable viscosity modifying agent has repeated units of the following structure:R1 is a methyl group or a hydrogen. R2 is a straight, branched or cyclic alkyl group having from 1 to 6 carbon atoms. R3 is a straight, branched or cyclic alkyl group having from 1 to 12 carbon atoms, and n is 2 or more.