Hyaluronic Acid Hydrogels with Vitamin A Cyclodextrin Complexes
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Solution Overview
Problem
Skin aging is challenging due to endogenous and exogenous factors, leading to collagen breakdown and reduced mechanical tension in the dermal connective tissue, which existing treatments like hyaluronic acid compositions with retinol face solubility and stability issues, especially in aqueous environments.
Innovation Solution
A composition combining hyaluronic acid with a cyclodextrin complexed to vitamin A, including retinol and its esters, to enhance solubility and sustained release, thereby stimulating collagen production and regulating collagen-degrading enzymes, while maintaining stability in dermal fillers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If vitamin A esters are used in dermal fillers, then they provide sustained release and stability, but they become insoluble in aqueous environments
Solution Approach 1:
Cyclodextrin acts as a mediator between vitamin A esters and the aqueous environment. The cyclodextrin forms inclusion complexes with the hydrophobic vitamin A esters, enabling them to be dispersed and delivered in aqueous dermal filler compositions while maintaining their stability and sustained release properties
Solution Approach 2:
The patent changes the physical-chemical parameters of vitamin A esters by forming inclusion complexes with cyclodextrin. This transformation allows the ester forms to become water-soluble while maintaining their stability and sustained release characteristics, resolving the contradiction between solubility and stability
2Adaptability or versatility
If retinol is used in dermal fillers, then it can be metabolized to retinoic acid, but it faces solubility issues in aqueous environments
Solution Approach 1:
Cyclodextrin serves as an intermediary carrier for retinol in aqueous dermal filler compositions. The inclusion complex formation enables retinol to be delivered in water-based formulations while maintaining its ability to be metabolized by skin into retinoic acid
3Strength
If collagen synthesis is stimulated to prevent skin aging, then mechanical tension is improved, but matrix metalloproteins formation increases
Solution Approach 1:
The patent utilizes the parameter of vitamin A metabolism - when delivered via cyclodextrin inclusion complexes, vitamin A is metabolized to retinoic acid which selectively stimulates collagen synthesis while downregulating matrix metalloproteins, changing the balance between collagen production and degradation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively stimulates collagen production, downregulates collagen-degrading enzymes, and improves skin elasticity and hydration, addressing the challenges of skin aging by providing a stable and effective dermal filler solution.
Implementation Method 1
a cyclodextrin and vitamin A complexed to the cyclodextrin
Implementation Method 2
improve sustained release of vitamin A
Data Source
AI summary
Compositions, such as hydrogel compositions, that include a hyaluronic acid, a vitamin A, and a cyclodextrin may be used as medical or cosmetic fillers, implants, or creams. For example, the compositions may be used as dermal fillers.