Vitamin A Solid Particles for Stable Tablet Compression

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Solution Overview

Problem

Existing compressed tablets containing fat-soluble vitamins like vitamin A often suffer from ingredient loss during compression and storage, and they may not be suitable for vegetarians due to the use of animal-derived gelatin. Additionally, the inclusion of antioxidants can complicate formulations.

Innovation Solution

The development of solid particles comprising at least 20 weight-% of vitamin A and/or its derivatives, along with an emulsifier and a non-reducing sugar, without any antioxidants. These particles are designed to be highly stable and suitable for compression into tablets.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antioxidants are added to improve stability, then storage stability is improved, but formulation complexity increases

Engineering Contradiction:
Improvestorage stabilityVSAvoidformulation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The invention removes antioxidants from the formulation entirely, extracting the problematic component while maintaining stability through alternative means (encapsulation matrix and controlled release mechanism), thereby simplifying the formulation while preserving reliability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces an intermediary encapsulation matrix that mediates between the vitamin A and the external environment, protecting the vitamin without requiring direct antioxidant addition, thus achieving stability without formulation complexity

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If gelatin is used to formulate fat-soluble vitamins, then stability is improved, but vegetarian suitability is compromised

Engineering Contradiction:
ImprovestabilityVSAvoidvegetarian suitability
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention changes the material parameter of the encapsulation matrix from animal-derived gelatin to plant-based or synthetic polymers, maintaining the functional properties (stability and controlled release) while altering the source to accommodate vegetarian requirements

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent develops a universal encapsulation system that can serve multiple functions (stability, controlled release, vegetarian compatibility) through a single plant-based or synthetic polymer matrix, replacing the need for gelatin-specific formulations

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Ease of manufacture

If compression pressure is applied to produce tablets, then tablet formation is achieved, but vitamin A loss increases

Engineering Contradiction:
Improvetablet formationVSAvoidvitamin A loss
Core Design Contradiction:
Ease of manufactureVSLoss of substance

Solution Approach 1:

The invention performs preliminary encapsulation of vitamin A in a protective matrix before compression, pre-establishing the protection mechanism that will withstand the subsequent compression process, thereby preventing vitamin loss during tablet formation

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent creates a cushioning encapsulation structure around the vitamin A that absorbs and distributes compression forces, protecting the vitamin from mechanical damage and loss during the tablet pressing operation

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentUS20250041260A1Solid particles
Publication Date: 2025.02.06 DSM IP ASSETS BV

AI summary

Solid particles comprising vitamin A and/or its derivatives which are more stable when compressed into tablets are disclosed.