Vitamin B Complex Compositions for Age-Related Macular Degeneration

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Solution Overview

Problem

Age-related macular degeneration (AMD) is a leading cause of severe visual acuity loss, and existing treatments lack effective methods to prevent or slow its progression, particularly in early stages and across diverse populations.

Innovation Solution

Compositions comprising a potent vitamin B complex, including vitamin B1, B2, B3, B5, B6, B7, B9, and B12, administered to promote retinal health and reduce the risk of advanced AMD, with specific formulations ranging from 1.5 mg to 60 mg of various vitamins per day.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If high concentrations of vitamin B complex are administered, then ocular health is promoted and AMD progression is slowed, but the complexity of the composition increases

Engineering Contradiction:

Improveeffectiveness in preventing AMDVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple vitamin B complex members (B1, B2, B3, B5, B6, B7, B9, B12) into a single compositional formulation, merging their individual protective effects against AMD into one integrated therapeutic agent that addresses multiple pathological mechanisms simultaneously

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The vitamin B complex composition serves multiple functions: it acts as an antioxidant, anti-inflammatory agent, and metabolic regulator, providing universal protection against various mechanisms of AMD pathogenesis including oxidative stress, inflammation, and cellular metabolism dysfunction

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If specific high doses of individual vitamins are used, then therapeutic efficacy is improved, but the manufacturing precision requirements increase

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoiddosage formulation precision

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The patent specifies precise parameter ranges for each vitamin B member (e.g., B1: 0.1-10 mg, B2: 0.1-10 mg, B3: 1-50 mg, B6: 1-50 mg, B12: 0.1-10 mg) to optimize therapeutic efficacy while maintaining manufacturability, representing a deliberate change in dosage parameters from conventional supplements

Inventive Principle:

Principle #35Parameter changes

3Reliability

If vitamin B complex composition is administered early in disease progression, then prevention of advanced AMD is more effective, but the time required for treatment increases

Engineering Contradiction:

Improveprevention effectivenessVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent is designed for preliminary action by being administered in early stages of AMD or even in at-risk populations before significant vision loss occurs, preventing the disease from progressing to advanced stages rather than treating established severe damage

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS20230117576A1Compositions and methods for age related eye diseases comprising high concentrations of vitamins

Publication Date: 2023.04.20 BAUSCH & LOMB IRELAND LIMITED

AI summary

The present disclosure describes compositions comprising a potent vitamin B complex and pharmaceutically acceptable salts of any of the foregoing. The compositions are useful in methods for treating conditions associated with a loss of visual acuity including, for example, age-related macular degeneration.