Vitamin B Complex Synergistic Formulation for Enhanced Bioavailability
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Solution Overview
Problem
Existing vitamin supplement compositions face challenges with ingredient absorption, bioavailability, safety, and shelf life, necessitating the development of novel formulations with enhanced bioavailability for maximizing nutritional absorption.
Innovation Solution
A vitamin supplement composition comprising a complex of vitamin B6, vitamin B9, and vitamin B12 derivatives, specifically formulated to enhance bioavailability, along with additional vitamins, minerals, and amino acids, which cooperate synergistically to improve absorption and stability, and can be administered in various forms such as swallowable, chewable, or dissolvable tablets, capsules, or liquids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional vitamin supplement formulations are used, then the composition is simple and easy to manufacture, but the bioavailability and nutritional absorption are insufficient
Solution Approach 1:
The patent combines multiple vitamin B complex members (B1, B2, B3, B5, B6, B7, B9, B12) into a single synergistic formulation where each vitamin enhances the absorption and utilization of the others. This merging approach resolves the contradiction by creating a complex formulation that achieves high bioavailability through synergistic interactions among vitamin components.
Solution Approach 2:
The patent employs composite vitamin formulations that integrate multiple vitamin forms and ratios optimized for synergistic absorption. This composite approach allows the formulation to achieve enhanced bioavailability while maintaining manufacturability through established composite material processing techniques.
2Reliability
If vitamin formulations requiring multiple biochemical conversions are used, then the vitamins can be stored longer, but the absorption and utilization by the body are reduced
Solution Approach 1:
The patent pre-converts vitamins into their most bioavailable forms during manufacturing (e.g., using active B12 instead of cyanocobalamin, using 5-MTHF instead of folic acid) so that minimal additional conversions are needed in the body. This preliminary action resolves the contradiction by ensuring high absorption while maintaining stability through proper formulation and storage conditions.
Solution Approach 2:
The patent changes the chemical parameters of vitamins by selecting specific isomers, salts, and derivatives that offer optimal balance between stability for storage and bioavailability for absorption. For example, using specific ratios of riboflavin-5-phosphate and selecting stable derivative forms that require minimal metabolic conversion.
3Reliability
If high doses of individual vitamins are used, then the nutritional content is high, but the safety and tolerance are reduced due to interactions and metabolic burden
Solution Approach 1:
The patent applies local quality by providing each vitamin in specific forms and ratios that match the body's localized needs in different tissues and metabolic pathways. This approach allows high overall nutritional content while maintaining safety by distributing the vitamin load across multiple synergistic components rather than concentrating single high doses of individual vitamins.
Solution Approach 2:
The patent uses certain vitamins as intermediaries that facilitate the metabolism and utilization of other vitamins. For example, vitamin B6 serves as a cofactor in the metabolism of other B vitamins, and vitamin C enhances the absorption and stability of other vitamins. This intermediary approach allows high nutritional content to be delivered safely through coordinated metabolic pathways.
4Reliability
If conventional single-vitamin or simple multi-vitamin formulations are used, then the manufacturing process is straightforward, but the synergistic absorption and utilization are limited
Solution Approach 1:
The patent creates a universal vitamin B complex formulation where each component serves multiple functions: vitamins act as both standalone nutrients and as cofactors for other vitamins' metabolism. This multi-functionality allows the complex formulation to achieve synergistic absorption while using standard manufacturing processes for multiple ingredient mixing and encapsulation.
Data Source
AI summary
A vitamin supplement composition that includes a complex with enhanced bioavailability having a vitamin B complex, wherein the vitamin B complex includes: (a) a first vitamin, wherein the first vitamin comprises a form of vitamin B6; (b) a second vitamin, wherein the second vitamin comprises a form of vitamin B9; (c) a third vitamin, wherein the third vitamin comprises a form of vitamin B12; and (d) wherein the first vitamin, the second vitamin, and the third vitamin cooperate synergistically to enhance bioavailability of the same. The present invention further includes a method of administering a vitamin supplement composition to an individual having, for example, MTHFR deficiency.