Vitamin B Complex Synergistic Bioavailability Formulation

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Solution Overview

Problem

Existing vitamin supplements face issues with ingredient absorption, bioavailability, safety, and shelf life, necessitating novel compositions with enhanced bioavailability for maximizing nutritional absorption.

Innovation Solution

A vitamin supplement composition comprising a complex of vitamin B6, vitamin B9, and vitamin B12, specifically formulated to enhance bioavailability, along with other vitamins, minerals, and amino acids, which cooperate synergistically to improve absorption and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional vitamin supplements are used, then basic nutritional needs are met, but bioavailability and absorption are insufficient

Engineering Contradiction:
ImprovebioavailabilityVSAvoidnutritional absorption
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent combines multiple B vitamins (B6, B9, B12) into a synergistic complex formulation. This merging of complementary nutrients enhances overall bioavailability compared to individual supplements, as the vitamins work together to improve absorption and reduce biochemical conversion steps required by the body.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention changes the chemical form and formulation parameters of B vitamins to optimize absorption. Specifically, it uses reduced folate and activated forms of B vitamins that require fewer metabolic conversions, thereby improving bioavailability and nutritional absorption efficiency.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If multiple biochemical conversion steps are required, then vitamin activity is achieved, but absorption efficiency and shelf life are reduced

Engineering Contradiction:
Improvenutritional absorptionVSAvoidshelf life
Core Design Contradiction:
Quantity of substanceVSDuration of action of stationary object

Solution Approach 1:

The patent applies preliminary biochemical modifications to the vitamins during manufacturing, creating pre-activated or reduced forms (e.g., reduced folate, methylcobalamin). This preliminary action reduces the number of conversion steps needed in the body, improving absorption efficiency while the stable formulated complex extends shelf life by protecting these active forms from degradation.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The invention creates a composite vitamin complex where B6, B9, and B12 are formulated together with specific carriers and stabilizers. This composite structure protects the sensitive active vitamin forms during storage (extending shelf life) while maintaining their bioavailability and reducing conversion requirements upon ingestion.

Inventive Principle:
Principle #40Composite materials

Data Source

PatentUS10039765B1Vitamin supplement compositions with enhanced bioavailability
Publication Date: 2018.08.07 TOOTHMAN MICHELLE ANN

AI summary

A vitamin supplement composition that includes a complex with enhanced bioavailability having a vitamin B complex, wherein the vitamin B complex includes: (a) a first vitamin, wherein the first vitamin comprises a form of vitamin B6; (b) a second vitamin, wherein the second vitamin comprises a form of vitamin B9; (c) a third vitamin, wherein the third vitamin comprises a form of vitamin B12; and (d) wherein the first vitamin, the second vitamin, and the third vitamin cooperate synergistically to enhance bioavailability of the same. The present invention further includes a method of administering a vitamin supplement composition to an individual having, for example, known or unknown MTHFR CT polymorphism.