Vitamin C Eutectic Mixture Betaine Solubility Stability

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Solution Overview

Problem

Vitamin C has low solubility and stability in both aqueous and non-aqueous solvents, leading to rapid oxidation and precipitation, which limits its skin permeability and effectiveness in cosmetic compositions.

Innovation Solution

A cosmetic composition comprising a eutectic mixture of vitamin C and betaine, which increases solubility and stability, and improves skin permeability by forming a hydrogen-bonded complex, allowing for higher concentrations of vitamin C without precipitation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If vitamin C is dissolved in water in large amounts, then solubility is improved, but oxidation stability deteriorates due to rapid decomposition

Engineering Contradiction:

Improvesolubility of vitamin CVSAvoidoxidation stability of vitamin C

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent uses non-aqueous solvents (polyols like propylene glycol, butylene glycol, or glycerin) as intermediary substances to dissolve vitamin C. These solvents act as a mediator between vitamin C and water, providing a stable dissolution environment that prevents rapid oxidation while maintaining high solubility. The non-aqueous solvent system slows down the oxidation reaction rate while still allowing vitamin C to be dissolved in sufficient concentrations for cosmetic effectiveness.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If non-aqueous solvent is used to improve oxidation stability, then stability is improved, but solubility of vitamin C deteriorates due to extremely low solubility

Engineering Contradiction:

Improveoxidation stability of vitamin CVSAvoidsolubility of vitamin C

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent creates a composite solvent system combining non-aqueous solvents (polyols) with water in specific ratios (non-aqueous solvent: water = 9:1 to 1:9). This composite formulation leverages the oxidation stability of non-aqueous solvents while incorporating enough water to maintain vitamin C solubility. The synergistic combination allows the formulation to achieve both high stability and adequate solubility that neither component could achieve alone.

Inventive Principle:

Principle #40Composite materials

3Reliability

If vitamin C is stored at low temperatures to delay oxidation, then oxidation stability is improved, but precipitation occurs causing quality issues

Engineering Contradiction:

Improveoxidation stability of vitamin CVSAvoidphysical stability of vitamin C solution

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the solvent system parameters from purely aqueous to a non-aqueous dominant system (60-99 wt% non-aqueous solvent). This parameter change in the solvent composition fundamentally alters the temperature-dependent solubility behavior of vitamin C. The non-aqueous polyol solvent system maintains vitamin C in solution at low temperatures where aqueous systems would cause precipitation, while simultaneously providing the oxidation stability needed to delay decomposition over time.

Inventive Principle:

Principle #35Parameter changes

4Reliability

If vitamin C is dispersed in silicone-based oil, then oxidation stability is partially improved, but skin absorption deteriorates due to poor permeation of hydrophilic vitamin C through stratum corneum

Engineering Contradiction:

Improveoxidation stability of vitamin CVSAvoidskin permeability of vitamin C

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent changes the physical-chemical parameters of the solvent system from hydrophobic (silicone oil) to hydrophilic-compatible (non-aqueous polyols). This parameter change in solvent polarity and hydrogen-bonding capability allows the formulation to maintain oxidation stability while improving skin permeability. The non-aqueous polyol solvents create a dissolution state of vitamin C that is more compatible with the hydrophilic nature of skin barriers, enabling better penetration while preserving stability.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The eutectic mixture of vitamin C and betaine enhances vitamin C's solubility and stability, maintaining its effectiveness for skin brightening, tone uniformity, wrinkle improvement, and elasticity, even at low temperatures, with improved skin permeability and prolonged oxidation stability.

Implementation Method 1

a eutectic mixture containing vitamin C and betaine... forming a hydrogen-bonded complex

Methodology Applied

Scientific EffectHydrogen bonding: Chemical Bonding

Implementation Method 2

vitamin C remains stable without being precipitated... excellent oxidation stability

Methodology Applied

Scientific EffectOxidation prevention: Oxidation

Data Source

PatentUS20240390254A1Cosmetic composition comprising eutectic mixture of vitamin c

Publication Date: 2024.11.28 LG HOUSEHOLD & HEALTH CARE LTD

AI summary

The present invention relates to a cosmetic compound comprising a eutectic mixture containing vitamin C and betaine and a preparation method therefor and can provide a cosmetic composition that contains vitamin C in the form of a eutectic mixture and thus exhibits high solubility in various types of solvents, excellent oxidation stability, and high skin permeability.