Vitamin D3 Sphingomyelin Composition for Neurite Maturation

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Solution Overview

Problem

Current compositions do not optimize the link between cholecalciferol (vitamin D3) and its receptor (VDR) to amplify its functions, particularly for central nervous system maturation.

Innovation Solution

A composition comprising vitamin D3 and sphingomyelin, with a ratio of vitamin D3 to sphingomyelin equal to or greater than 50:1 (IU/mg), is administered to promote, support, or optimize the formation and outgrowth of neurites of nervous system cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If dietary compositions contain vitamin D3 and sphingomyelin, then the link between cholecalciferol and its receptor (VDR) is optimized and central nervous system maturation is promoted, but the specific ratio optimization is not achieved in prior art compositions

Engineering Contradiction:

Improvelink between cholecalciferol and VDR receptorVSAvoidcentral nervous system maturation efficiency

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The invention optimizes the ratio parameter of vitamin D3 to sphingomyelin (equal to or greater than 50:1 IU/mg) to maximize the functional link between cholecalciferol and its VDR receptor, thereby enhancing central nervous system maturation effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite composition combining vitamin D3 and sphingomyelin in a specific ratio, where sphingomyelin-rich lipid microdomains serve as a platform to concentrate and present cholecalciferol to VDR receptors, amplifying the biological effect

Inventive Principle:

Principle #40Composite materials

2Reliability

If compositions use vitamin D3 alone, then bone and muscle function is supported, but the amplification effect on central nervous system maturation is not achieved

Engineering Contradiction:

Improvebone and muscle functionVSAvoidneurite formation and outgrowth

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The invention merges vitamin D3 with sphingomyelin in a specific composition, combining the known benefits for bone and muscle function with enhanced central nervous system maturation effects through optimized receptor interaction

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Sphingomyelin acts as an intermediary that facilitates the interaction between vitamin D3 and VDR receptors by creating lipid microdomains that concentrate the receptor-ligand complex, thereby amplifying the biological response

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly increases the length of neurites and the volume of cells, enhancing the maturation of nervous system cells compared to prior art compositions.

Implementation Method 1

the cholecalciferol needs to be bound to its receptor (VDR), present in lipid microdomains rich in sphingomyelin content

Methodology Applied

Scientific EffectLipid microdomain formation:

Data Source

PatentUS20250049826A1Composition for promoting the maturing of the central nervous system

Publication Date: 2025.02.13 BUONA SPA SOCIETA BENEFIT

AI summary

A composition for promoting the maturing of the nervous system comprising vitamin D3 and sphingomyelin.