Water-Soluble Vitamin E Derivatives for Non-Polar Solubility
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Solution Overview
Problem
Current products for human consumption, such as food and beverages, face challenges in incorporating non-polar compounds due to their poor water solubility, leading to limited concentrations and undesirable organoleptic properties when higher amounts are included.
Innovation Solution
Development of high dimer-containing water-soluble vitamin E derivative compositions that include a mixture of dimer and monomer forms of vitamin E derivatives, such as TPGS, to enhance the solubility and stability of non-polar ingredients like polyunsaturated fatty acids and coenzyme Q10, allowing for higher concentrations in food and beverages without compromising clarity and taste.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If non-polar compounds are included in food and beverages, then the concentration of bioactive ingredients can be increased, but the water solubility decreases leading to poor dissolution and undesirable organoleptic properties
Solution Approach 1:
The patent employs water-soluble vitamin E derivatives (tocopheryl polyethylene glycol succinate and related compounds) as intermediary substances that act as solubilizing agents. These derivatives have both hydrophilic (water-loving) and lipophilic (fat-loving) characteristics, enabling them to bridge the gap between water-based beverage matrices and non-polar bioactive ingredients, thereby enhancing solubility without compromising the concentration of active compounds
Solution Approach 2:
The invention creates composite formulations by combining water-soluble vitamin E derivatives with non-polar compounds in specific ratios. This composite approach allows the formulation to exhibit properties of both components: the water solubility of the vitamin E derivative and the bioactivity of the non-polar compound, enabling higher concentrations to be incorporated while maintaining desirable organoleptic properties
2Quantity of substance
If higher amounts of non-polar ingredients are included, then the effectiveness of bioactive delivery is improved, but the clarity and taste of the beverage deteriorate
Solution Approach 1:
Water-soluble vitamin E derivatives serve as intermediary solubilizing agents that enable higher concentrations of non-polar bioactive ingredients to be incorporated into beverages. These derivatives form micellar structures that encapsulate the non-polar compounds, preventing them from separating out and causing undesirable effects such as cloudiness, off-flavors, or precipitation, thus allowing effective dosing while maintaining beverage quality
Solution Approach 2:
The patent utilizes parameter changes in the molecular structure of vitamin E derivatives, specifically varying the polyethylene glycol chain length and composition, to optimize the balance between solubilizing capacity and beverage compatibility. By adjusting these molecular parameters, the formulation can accommodate higher amounts of non-polar ingredients while maintaining clarity and taste
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The high dimer-containing vitamin E derivative compositions improve the solubility and stability of non-polar compounds, enabling higher concentrations in food and beverages, maintaining clarity and desirable organoleptic properties, and providing a more effective delivery of bioactive ingredients.
Implementation Method 1
The water-soluble vitamin E derivative mixtures contain mixtures of dimers and monomers of the vitamin E derivative... enhance the solubility and stability of non-polar ingredients
Implementation Method 2
water-soluble vitamin E derivative compositions that include a mixture of dimer and monomer forms of vitamin E derivatives, such as TPGS, to enhance the solubility and stability of non-polar ingredients
Data Source
AI summary
Provided herein are compositions that contain water-soluble vitamin E derivative mixtures (compositions), such as tocopheryl polyethylene glycol succinate (TPGS), TPGS analogs, TPGS homologs and TPGS derivatives. The water-soluble vitamin E mixtures contain mixtures of dimers and monomers of the vitamin E derivative. Provided are products containing the water-soluble vitamin E derivative mixtures, including capsules, soft gel compositions, pre-gel compositions, emulsions and powders.