Vitamin K2 Composition for Cardiovascular Calcification Control

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Solution Overview

Problem

Existing vitamin K2 products suffer from low bioavailability, instability due to sensitivity to light and heat, and lack targeted functionality for preventing cardiovascular calcification, particularly in individuals taking statin drugs.

Innovation Solution

A vitamin K2-containing pharmaceutical composition comprising specific ratios of active ingredients that promote calcium absorption, inhibit calcification, and provide daily health protection, including vitamin D3, vitamin K2, Ω-3 fatty acid, pyrroloquinoline quinone, and coenzyme Q10, formulated to enhance stability and bioavailability through a dual-protection mode.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If vitamin K2 is used as a dietary supplement to promote calcium absorption, then bone health is improved, but cardiovascular calcification may be promoted due to lack of targeted functionality

Engineering Contradiction:

Improvebone health protectionVSAvoidcardiovascular calcification risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by directing calcium to specific locations: bones and teeth (where it is needed) versus blood vessels (where it should be prevented). Vitamin K2 activates osteocalcin to bind calcium in bone tissue, while the composition prevents calcium deposition in cardiovascular tissue, achieving location-specific calcium management.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

Vitamin K2 acts as an intermediary molecule that regulates calcium binding proteins. It activates osteocalcin (promoting bone calcium deposition) and matrix Gla protein (inhibiting vascular calcium deposition), thereby mediating calcium distribution between different tissues and preventing harmful calcification.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of operation

If vitamin K2 is administered orally, then it can be taken conveniently, but bioavailability is low due to fat-solubility and poor intestinal absorption

Engineering Contradiction:

Improveoral administration convenienceVSAvoidbioavailability

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent uses composite materials by combining vitamin K2 with phospholipids (such as lecithin) and other auxiliary ingredients to form a composite preparation. This composite structure improves the solubility and absorption of fat-soluble vitamin K2 in the aqueous intestinal environment, thereby enhancing bioavailability while maintaining oral administration convenience.

Inventive Principle:

Principle #40Composite materials

3Duration of action of stationary object

If conventional vitamin K2 products are stored for long periods, then shelf life is extended, but biological activity is seriously reduced due to sensitivity to light and heat

Engineering Contradiction:

Improveshelf lifeVSAvoidbiological activity

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent employs inert atmosphere or protective packaging that shields vitamin K2 from light and heat exposure during storage. By creating a protected environment that excludes degrading factors (light and heat), the preparation maintains its biological activity over extended storage periods, effectively resolving the contradiction between shelf life and activity retention.

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

Solution Approach 2:

The patent applies beforehand cushioning by incorporating antioxidants and stabilizers into the formulation, and using light-blocking packaging materials. These protective measures are built into the product design in advance, cushioning vitamin K2 against degradation from light and heat exposure during storage, thereby preserving biological activity throughout the shelf life.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentUS20250221946A1Pharmaceutical composition containing vitamin k2 for improving cardiovascular calcification, preparation method therefor and use thereof

Publication Date: 2025.07.10 NANJING SHENGDE INST OF BIOTECHNOLOGY CO LTD

AI summary

A vitamin K2-containing pharmaceutical composition for improving cardiovascular calcification is provided. The pharmaceutical composition includes a first component, a second component and a third component, with the mass ratio of (0.1-5):(0.01-0.5):(100-500). The preparation method and use of the pharmaceutical composition are also provided. The pharmaceutical composition can comprehensively prevent and block cardiovascular calcification, and is particularly suitable for reversing the cardiovascular calcification symptom due to taking statin drugs. Meanwhile, the pharmaceutical composition can provide daily health support and protection for the heart. The pharmaceutical composition of the present disclosure is characterized by stable active ingredients, high bioavailability, strong targeting and no side effect, achieving the purpose of prevention and treatment simultaneously.