Vitamin K2 Nanoparticles for MK-7 Solubility and Absorption
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing formulations of vitamin K2, particularly MK-7, suffer from poor solubility and stability issues, leading to inadequate absorption and effectiveness in treating conditions such as vascular calcification and bone diseases in patients with chronic kidney disease (CKD), and there is a need for improved delivery methods to enhance bioavailability and therapeutic efficacy.
Innovation Solution
Development of nano-sized particles of vitamin K2, specifically MK-7, with controlled particle sizes and stabilizing agents, enhancing solubility and stability, and administered in formulations that increase bioavailability and therapeutic effectiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If vitamin K2 (MK-7) is administered in conventional formulations, then it can be provided as a dietary supplement, but it suffers from poor solubility and inadequate absorption
Solution Approach 1:
The patent transforms vitamin K2 from conventional bulk form into nano-sized particles (1-1000 nm), fundamentally changing the physical parameter of particle size. This parameter change dramatically increases the surface area to volume ratio, thereby improving solubility and absorption effectiveness in biological systems
Solution Approach 2:
The vitamin K2 compound is segmented into numerous nano-sized particles rather than administered as a single bulk form. This segmentation increases the total surface area available for dissolution and absorption, resolving the contradiction between maintaining adequate dosage quantity and improving solubility/absorption effectiveness
2Ease of operation
If conventional vitamin K2 formulations are used, then they can be administered easily, but they exhibit poor stability
Solution Approach 1:
The patent creates a composite nano-formulation where vitamin K2 is combined with stabilizing agents and delivery vehicle materials at the nanoscale. This composite structure protects the vitamin K2 from degradation while maintaining administration convenience through various delivery forms (injections, oral formulations, topical applications)
3Quantity of substance
If higher doses of vitamin K2 are administered to overcome poor absorption, then more active ingredient is provided, but solubility limitations prevent adequate bioavailability
Solution Approach 1:
By changing the particle size parameter to the nanoscale range (1-1000 nm), the formulation can deliver higher effective doses because the increased surface area dramatically improves dissolution rate and bioavailability, overcoming the solubility limitations that would otherwise prevent adequate absorption of higher doses
Data Source
AI summary
The present application discloses compositions comprising nanoparticles of vitamin K2, and their methods of use.