Vitis Vinifera Leaf Extract Composition for Noise-Induced Tinnitus

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Solution Overview

Problem

Current treatments for tinnitus, such as blood flow enhancement vasodilators and natural Ginkgo biloba extracts, do not effectively alleviate tinnitus symptoms, and there is a lack of FDA-approved medications for this condition.

Innovation Solution

A pharmaceutical and food composition utilizing Vitis vinifera leaf extract as an active ingredient, administered in a pharmaceutically effective amount, to alleviate or ameliorate tinnitus symptoms.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If Ginkgo biloba extract (EGb 761) is used for treating tinnitus, then the treatment duration is extended to 3-6 months, but the efficacy does not exceed placebo performance

Engineering Contradiction:

Improvetinnitus treatment efficacyVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent changes the active ingredient from Ginkgo biloba extract to Vitis vinifera leaf extract, which contains different polyphenolic compounds (particularly proanthocyanidins and flavonoids). This chemical composition change results in superior tinnitus relief efficacy compared to Ginkgo biloba, achieving significant symptom reduction within a shorter treatment period while maintaining reliability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs a natural plant extract (Vitis vinifera leaf extract) that can be administered in a shorter duration compared to Ginkgo biloba extract. The treatment achieves effective tinnitus management in a compressed timeframe, reducing the burden of long-term medication while maintaining or improving efficacy

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If blood flow enhancement vasodilators are prescribed for tinnitus treatment, then the treatment approach is pharmacological, but no FDA-approved medication exists and efficacy is limited

Engineering Contradiction:

Improvetinnitus treatment effectivenessVSAvoidavailability of approved medications

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent uses Vitis vinifera leaf extract as a natural intermediary substance that addresses tinnitus through multiple mechanisms including antioxidant activity, anti-inflammatory effects, and improved microcirculation. This natural compound serves as an effective mediator that achieves therapeutic results without requiring FDA approval processes, bridging the gap between conventional pharmacology and natural remedy effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent utilizes Vitis vinifera leaf extract which contains a composite of multiple bioactive compounds including proanthocyanidins, flavonoids, and other polyphenols. This composite natural material provides synergistic effects that enhance tinnitus treatment effectiveness compared to single-compound pharmaceuticals, offering a versatile therapeutic approach

Inventive Principle:

Principle #40Composite materials

3Reliability

If Vitis vinifera leaf extract is used for treating noise-induced hearing loss, then antioxidant effects are demonstrated, but the effect on tinnitus prevention or treatment was previously unknown

Engineering Contradiction:

Improvetinnitus symptom reliefVSAvoidknowledge about tinnitus treatment effect

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent applies Vitis vinifera leaf extract preventively and therapeutically for tinnitus based on its known antioxidant properties that were previously demonstrated in noise-induced hearing loss models. The extract's polyphenolic compounds provide preliminary protection against oxidative stress in the auditory system, and continue to provide therapeutic benefits for existing tinnitus symptoms, expanding the known applications of this natural extract

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The Vitis vinifera leaf extract significantly reduces noise-induced tinnitus symptoms by increasing gap-prepulse inhibition of acoustic startle and improving histological outcomes, demonstrating effective treatment and prevention of tinnitus.

Implementation Method 1

Vitis vinifera leaves are composed of many polyphenols, including anthocyanins, flavonoids, and organic acids... One such polyphenol, proanthocyanidin, has been used for various purposes, such as antioxidants

Methodology Applied

Scientific EffectAntioxidant effect: Oxidation

Data Source

PatentUS12611437B2Composition for preventing or treating tinnitus comprising <i>Vitis vinifera</i>leaf extract as active ingredient

Publication Date: 2026.04.28 AJOU UNIV IND ACADEMIC COOP FOUND

AI summary

A composition containing a Vitis vinifera leaf extract as an active ingredient and its uses in preventing or treating tinnitus are disclosed. The composition may be a pharmaceutical composition or a food composition. The composition containing a Vitis vinifera leaf extract as an active ingredient is excellent in alleviating and improving tinnitus caused by noise and the like, and therefore is very useful as a composition for preventing or treating tinnitus.