Vitis Vinifera Leaf Extract Enrichment via Membrane Filtration
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Solution Overview
Problem
Current methods for extracting compounds from Vitis vinifera L. leaves are complex, costly, and result in extracts with significant deviations from reference extracts, lacking effective anti-inflammatory properties for treating venous insufficiency and other inflammatory diseases.
Innovation Solution
A process involving the extraction of Vitis vinifera L. leaves using water or ethanol mixtures, followed by separation, partial eluent removal, redissolution, and selective enrichment through 2-phase extraction or membrane filtration, achieving a high flavonoid and anthocyanin content with enhanced anti-inflammatory effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If complex extraction methods are used to obtain high flavonoid content, then the anti-inflammatory efficacy is improved, but the manufacturing cost and process complexity increase
Solution Approach 1:
The extraction process is divided into distinct stages: initial extraction with water or ethanol, separation of crude extract, selective enrichment of flavonoids and anthocyanins, and final formulation. This segmentation allows each stage to be optimized independently, achieving high anti-inflammatory efficacy through cumulative enrichment rather than relying on a single complex extraction method.
Solution Approach 2:
The patent uses selective enrichment steps as intermediary processes between initial extraction and final product formulation. These intermediary steps concentrate flavonoids and anthocyanins specifically, acting as mediators that bridge the gap between simple extraction and high-efficacy final product, thereby improving anti-inflammatory properties without requiring the initial extraction to be inherently complex.
2Reliability
If selective enrichment of flavonoids and anthocyanins is performed through additional extraction steps, then the anti-inflammatory properties are enhanced, but the production time and cost increase
Solution Approach 1:
The patent employs parameter changes in the enrichment steps, specifically adjusting solvent composition, pH, and temperature conditions to selectively concentrate flavonoids and anthocyanins. By optimizing these parameters, the enrichment process achieves high anti-inflammatory properties efficiently, reducing the number of repeated extraction cycles needed and thereby minimizing additional production time.
3Ease of manufacture
If traditional extraction methods are used, then the process is simple, but the extract lacks sufficient anti-inflammatory properties for treating venous insufficiency
Solution Approach 1:
The patent performs preliminary selective enrichment of flavonoids and anthocyanins before final formulation. This preliminary action ensures that the active anti-inflammatory components are concentrated in advance, so that the subsequent formulation process remains simple while the final product possesses sufficient anti-inflammatory properties for treating venous insufficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process produces extracts with a flavonoid content of at least 15% and anthocyanin content of 0.1%, demonstrating increased inhibition of permeability-triggering cytokines, offering improved anti-inflammatory effects for treating venous insufficiency and other inflammatory conditions.
Implementation Method 1
extraction of the drug with an eluent selected from water and mixtures of water with alcohol, obtaining a crude extract
Implementation Method 2
extraction of the drug with an eluent selected from water and mixtures of water with alcohol
Implementation Method 3
selective enrichment of secondary plant ingredients by i. a 2-phase extraction
Implementation Method 4
selective enrichment of secondary plant ingredients by ii. a membrane filtration
Implementation Method 5
at least partially removing the eluent, obtaining thick extract
Data Source
AI summary
The application relates to a method for producing an extract from Vitis vinifera L. leaves, having the following steps: a) preparing a drug from Vitis vinifera L. leaves; b) extracting the drug with an eluent selected from water and mixtures of water and alcohol, thereby obtaining a raw extract; c) separating the raw extract from the extracted drug; d) at least partly removing the eluent, thereby obtaining a thick extract; e) redissolving the thick extract in water; f) separating insoluble components; and g) selectively enriching secondary plant contents by means of i. two-phase extraction or ii. membrane filtration. The application also relates to the extract obtained in this manner, to pharmaceutical preparations containing said extract, and to the use thereof.