Vitis vinifera Leaf Extract for Noise-Induced Hearing Loss
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Solution Overview
Problem
Current treatments for noise-induced hearing loss are inadequate, with no approved drugs for prevention or treatment, and existing studies on antioxidants and other substances have limited progress to clinical trials, highlighting the need for effective agents to prevent and treat hearing loss caused by noise exposure.
Innovation Solution
A pharmaceutical and food composition containing Vitis vinifera leaf extract as an active ingredient, which is shown to suppress the increase in hearing threshold caused by noise and inhibit cytotoxicity and cell death in auditory cells, thereby preventing or treating noise-induced hearing loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If noise exposure occurs in industrial and leisure environments, then hearing loss increases, but no effective drugs or treatments are available to prevent or treat it
Solution Approach 1:
The patent applies preliminary action by administering the Vitis vinifera leaf extract before noise exposure to prevent hearing loss. The extract is given at predetermined time points (e.g., 1 hour before noise exposure) to proactively protect auditory cells from upcoming noise damage, rather than treating after damage occurs.
Solution Approach 2:
The Vitis vinifera leaf extract acts as an intermediary substance that mediates between noise exposure and auditory cell damage. The extract contains antioxidant compounds that intervene in the pathological process, reducing oxidative stress and preventing cell death caused by noise exposure.
2Reliability
If antioxidants and other substances are studied for hearing loss prevention, then some show potential effects, but progress to clinical trials is limited
Solution Approach 1:
The patent utilizes a natural plant extract (Vitis vinifera leaf extract) that is relatively inexpensive to produce and obtain compared to synthesized pharmaceutical compounds. This natural extract can be readily sourced and tested, potentially accelerating the transition from preclinical to clinical stages.
Solution Approach 2:
The patent identifies specific parameters of the Vitis vinifera leaf extract (such as antioxidant activity, concentration ranges, and administration timing) that can be optimized to enhance protective effects while reducing required doses and improving bioavailability, thereby facilitating clinical development.
3Reliability
If hearing loss becomes severe, then assistive devices like hearing aids are less effective, but prevention mechanisms are insufficient
Solution Approach 1:
The patent applies preliminary anti-action by using the Vitis vinifera leaf extract to counteract the harmful effects of noise exposure before they can cause severe hearing loss. The extract preemptively protects auditory cells from oxidative stress and apoptosis, preventing the progression to severe hearing impairment where assistive devices become less effective.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Vitis vinifera leaf extract significantly decreases hearing thresholds, increases antioxidant enzyme expression, and inhibits cytotoxicity and cell death, demonstrating its effectiveness in preventing and treating noise-induced hearing loss.
Implementation Method 1
it has been disclosed that a grape leaf extract has an antioxidant effect
Implementation Method 2
inhibit cytotoxicity and cell death in auditory cells
Data Source
AI summary
A composition for preventing or treating hearing loss, containing a Vitis vinifera leaf extract as an active ingredient, is disclosed. A pharmaceutical composition for preventing or treating hearing loss, containing the extract (a Vitis vinifera leaf extract) as an active ingredient, protects auditory hair cells in the cochlea and spiral ganglion cells from damage caused by noise and the like and effectively reduces the hearing threshold measured in the auditory nerves, thereby being usable as an agent for preventing or treating hearing loss.