Modular Vivarium Pod Assembly with Sterile Doorway Junctions

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Solution Overview

Problem

Existing vivariums are expensive, time-consuming to build, and not modular, making it difficult to expand or perform maintenance while operational, and they lack the ability to maintain a sterile environment effectively.

Innovation Solution

A modular vivarium system composed of interconnected pre-made units or pods, such as cage-rack, hallway, HVACPIT, ingress, and egress pods, constructed from standard shipping containers, allowing for rapid expansion, reconfiguration, and maintenance without disrupting operations, with specialized doorways to maintain sterility and efficient airflow and supply management.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional vivarium construction methods are used, then a sterile environment can be maintained, but the construction process is expensive and time-consuming

Engineering Contradiction:
Improvesterile environment maintenanceVSAvoidconstruction time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The vivarium is divided into separate modular pods (cage-rack pods, hallway pods, HVACPIT pods, ingress pods, egress pods) that can be manufactured independently and then assembled. This segmentation allows parallel construction of multiple components simultaneously, dramatically reducing total construction time while maintaining sterile integrity through specialized connection doorways between pods.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Each pod is pre-manufactured, pre-assembled, and pre-sterilized as a complete functional unit before being transported to the final assembly location. This preliminary preparation eliminates the need for time-consuming on-site construction and allows the vivarium to be assembled rapidly by simply connecting the pre-prepared modules.

Inventive Principle:
Principle #10Preliminary action

2Reliability

If traditional vivarium construction methods are used, then a sterile environment can be maintained, but the construction process is expensive

Engineering Contradiction:
Improvesterile environment maintenanceVSAvoidconstruction cost
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

By segmenting the vivarium into standardized modular pods, the system can leverage economies of scale in manufacturing. Each pod type can be produced using optimized processes and can share common components, reducing per-unit costs. The modular approach also simplifies logistics and reduces the need for expensive custom fabrication.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The modular pods are designed as universal, multi-functional units that can serve multiple purposes. For example, hallway pods provide both structural support and serve as distribution corridors for utilities. This universality reduces the total number of specialized components needed, lowering overall construction costs while maintaining sterile integrity through standardized connection interfaces.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If traditional vivarium design is used, then the facility is built as a fixed structure, but expansion or maintenance requires shutting down operations

Engineering Contradiction:
Improvesterile environment maintenanceVSAvoidexpansion capability
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The vivarium transitions from a fixed, monolithic structure to a dynamic, reconfigurable modular system. Pods can be added, removed, or repositioned based on changing research needs. The standardized connection interfaces allow for flexible reconfiguration without compromising sterile barriers, enabling the facility to adapt to future requirements while maintaining operational continuity.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The modular pod architecture enables independent expansion of specific functional areas without affecting the entire facility. Additional cage-rack pods or HVACPIT pods can be connected to the hallway spine as needed, allowing progressive expansion that maintains sterile integrity through specialized doorway connections while keeping operations uninterrupted.

Inventive Principle:
Principle #1Segmentation

4Reliability

If traditional vivarium design is used, then the facility is built as a fixed structure, but maintenance cannot be performed while operational

Engineering Contradiction:
Improvesterile environment maintenanceVSAvoidmaintenance capability
Core Design Contradiction:
ReliabilityVSEase of repair

Solution Approach 1:

The vivarium is segmented into independently maintainable pods. If maintenance is needed, a specific pod can be isolated and serviced without affecting other operational areas. The standardized connection doorways allow for safe isolation and reconnection, enabling maintenance operations to proceed while the rest of the facility continues to operate under sterile conditions.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Pods are designed as self-contained units with all necessary components (HVAC, power, IT, cage racks) integrated beforehand. This preliminary configuration allows for rapid replacement or maintenance of entire pods as single units, eliminating the need for complex in-situ repairs and minimizing disruption to operational areas.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS10306866B1Method of assembly of a modular sterile facility
Publication Date: 2019.06.04 RECURSION PHARMACEUTICALS INC
  • US10306866B1 patent drawing
  • US10306866B1 patent drawing
  • US10306866B1 patent drawing

AI summary

A modular vivarium is assembled from pre-manufactured, transportable, sterile modules of distinct types, called pods. A hallway pod forms a spine, with cage-rack pods, ingress/egress pods and optional HVACPIT pods providing HVAC, power and IT services connected as spur pods to the hallway. Supplies and waste are also within modular pods. Temporary or single-use seals cover doorways during transit. Modules are joined or removed while maintaining sterility on both sides of the flush-to-wall doorway junction. A spur pod is sterilely connected to a hallway pod by aligning respective doors proximal, placing a seal between the pods around the doorways, sterilizing air between the pods, then removing the temporary seals from each doorway. Pods may be constructed from easily transportable ISO intermodal containers.