Simultaneous VOC and Liquid Biomolecule Analysis for Health Assessment
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Solution Overview
Problem
Current medical diagnostics lack a comprehensive, non-invasive method to assess a patient's health status in real-time, failing to simultaneously analyze both liquid and gas components from a single sample effectively.
Innovation Solution
A system and method that utilize a device capable of simultaneously analyzing both volatile organic compounds (VOCs) and larger molecules from a single bio-sample, integrating liquid and gas analysis sensor arrays to provide a comprehensive health assessment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If only VOC analysis is performed, then volatile compound detection is achieved, but comprehensive health assessment is limited
Solution Approach 1:
The patent combines VOC analysis and liquid biomolecule analysis into a single integrated device that processes both gas-phase and liquid-phase components from the same breath sample simultaneously, resolving the contradiction by merging two separate analytical functions into one unified system
Solution Approach 2:
The device performs multiple diagnostic functions including VOC detection, liquid biomolecule analysis, and comprehensive health assessment through a single multi-functional platform, allowing one device to replace multiple separate diagnostic tools
2Measurement precision
If invasive procedures are used for comprehensive health assessment, then diagnostic accuracy is improved, but patient comfort and accessibility deteriorate
Solution Approach 1:
The patent extracts and analyzes both volatile and non-volatile biomolecules from breath condensate, a non-invasive sample type, thereby achieving comprehensive health assessment without requiring invasive procedures like blood draws or tissue biopsies
Solution Approach 2:
The device uses breath condensate as an intermediary medium that contains both VOCs and liquid biomolecules, allowing indirect yet comprehensive assessment of health status through a non-invasive sampling method
3Measurement precision
If separate analysis of VOCs and liquid samples is performed, then specialized detection is achieved, but time efficiency and productivity decrease
Solution Approach 1:
The system merges separate VOC and liquid analysis workflows into a single simultaneous processing operation, where both gas-phase and liquid-phase analytes are detected in parallel from the same sample, thereby maintaining detection specificity while doubling productivity
Solution Approach 2:
The device performs continuous simultaneous analysis of both VOC and liquid biomolecules without requiring sequential processing steps, eliminating idle time between measurements and maximizing testing throughput
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables early detection and monitoring of diseases, reduces the need for invasive procedures, and provides a longitudinal view of an individual's health status over time, allowing for timely interventions and improved patient outcomes.
Implementation Method 1
The device is an array of sensor elements, each sensor element comprising a sensing surface... each sensor element is capable of interacting with at least one targeted compound... to signal the proximity or presence of the targeted compound
Data Source
AI summary
The present invention provides an improved system, device, and method for determining a comprehensive state of health in real time using non-invasive patient testing. The invention characterizes disease and other states of health by simultaneously assaying both liquid and gas in a sample or samples. During metabolism, the body performs a large variety of biochemical reactions. Reaction products, reaction by-products, and breakdown products are transported by the circulatory system throughout the body. Many of these molecular products are labile and volatilize into gases from bodily liquids. In gas form, these compounds appear as volatile organic compounds (VOCs).