Volatile Benzoxaborole Delivery for Agricultural Pathogen Control

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Solution Overview

Problem

There is a need for new uses of volatile antimicrobial agents and combinations with volatile plant growth regulators, particularly for agricultural applications, as existing oxaborole compounds have not been utilized in this context.

Innovation Solution

The use of volatile antimicrobial compounds, such as benzoxaboroles, is proposed for treating pathogens affecting meats, plants, or plant parts, combined with volatile plant growth regulators like 1-methylcyclopropene, and delivery systems are provided to leverage their volatility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If oxaborole compounds are used as antimicrobial agents, then antimicrobial activity is achieved, but volatility is insufficient for agricultural application

Engineering Contradiction:
Improveantimicrobial activityVSAvoidvolatility
Core Design Contradiction:
ReliabilityVSTemperature

Solution Approach 1:

The patent modifies the oxaborole compound structure by introducing specific substituents (fluorine, chlorine, methyl groups at defined positions) to adjust the molecular properties. These parameter changes in chemical structure enhance the volatility of the compound while preserving its antimicrobial core structure, enabling it to vaporize at agricultural application temperatures.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention creates composite volatile formulations by combining the modified oxaborole compounds with carrier materials or adjuvants that enhance volatility. These composite materials allow the antimicrobial agent to be delivered in a volatile form suitable for fogging and aerial application, while maintaining the biological activity of the oxaborole core.

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If new volatile antimicrobial applications are developed, then agricultural protection is enhanced, but existing compound utility is underutilized

Engineering Contradiction:
Improveagricultural application capabilityVSAvoidunderutilization of existing compounds
Core Design Contradiction:
Adaptability or versatilityVSLoss of substance

Solution Approach 1:

The patent extends the utility of oxaborole compounds by demonstrating their dual functionality: maintaining their known antimicrobial properties while adding a new volatile delivery mode for agricultural use. This multi-functionality allows the same compound class to serve both traditional and volatile aerosol applications, maximizing the value of existing chemical structures.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention performs preliminary structural optimization of oxaborole compounds to pre-establish volatility characteristics before agricultural application. By pre-modifying the molecular structure with volatility-enhancing groups, the compounds are prepared in advance for aerosol delivery, eliminating the need for complex field modification and enabling direct agricultural deployment.

Inventive Principle:
Principle #10Preliminary action

3Object-affected harmful factors

If volatile delivery systems are implemented, then pathogen coverage is improved, but delivery system complexity increases

Engineering Contradiction:
Improvepathogen coverage effectivenessVSAvoiddelivery system complexity
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The modified oxaborole compounds possess inherent volatility that enables self-delivery as a vapor or aerosol without requiring complex external delivery infrastructure. The compounds' own physical properties drive the delivery mechanism, eliminating the need for sophisticated pressurized systems or complex dispensing equipment, thus reducing overall system complexity while maintaining effective pathogen coverage.

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS12490742B2Volatile applications against pathogens
Publication Date: 2025.12.09 AGROFRESH INC
  • US12490742B2 patent drawing
  • US12490742B2 patent drawing
  • US12490742B2 patent drawing

AI summary

This invention is related to the use of a volatile antimicrobial compound against pathogens. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.