Volatile Lipophilic Compound Formulation for Concentration Retention
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Solution Overview
Problem
The challenge in manufacturing compositions and dosage forms containing volatile lipophilic compounds is the significant loss of these compounds during the manufacturing process due to their volatility, leading to reduced concentrations and increased production costs.
Innovation Solution
A method involving combining volatile lipophilic compounds with water-insoluble components to form a mixture, which is then processed using methods that increase vapor pressure, and optionally incorporating surface-active agents and water-soluble components to create an emulsion, thereby stabilizing the volatile compounds and minimizing their loss.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If volatile lipophilic compounds are processed using conventional manufacturing methods, then production efficiency is maintained, but significant loss of volatile compounds occurs due to increased vapor pressure
Solution Approach 1:
The patent introduces water-insoluble components as intermediary substances that form a mixture with volatile lipophilic compounds. This mixture acts as a mediator that reduces the vapor pressure of the volatile compounds during manufacturing processes, thereby minimizing their loss while maintaining production efficiency.
Solution Approach 2:
The patent changes the physical parameters of the volatile lipophilic compounds by combining them with water-insoluble components. This combination alters the vapor pressure parameter, reducing it from its conventional high value to a lower value that prevents compound loss during manufacturing while maintaining productivity.
2Manufacturing precision
If volatile lipophilic compounds are combined with water-insoluble components to reduce vapor pressure, then compound concentration is maintained, but manufacturing process complexity increases
Solution Approach 1:
The patent merges the volatile lipophilic compounds with water-insoluble components in a single mixing step to form a stable mixture. This combining approach simplifies the manufacturing process while achieving concentration consistency, as the mixture is formed in one operation rather than requiring multiple separate processing steps.
3Ease of manufacture
If conventional manufacturing methods are used without water-insoluble components, then manufacturing simplicity is maintained, but volatile compound loss increases leading to higher production costs
Solution Approach 1:
The patent uses water-insoluble components as intermediary substances that prevent volatile compound loss during manufacturing. Although this adds a component to the process, it eliminates the need for complex containment systems or specialized equipment, thereby maintaining ease of manufacture while reducing production costs through minimized losses.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method maintains at least 70-95% of the starting concentration of volatile lipophilic compounds in the final dosage form, reducing variability and production costs.
Implementation Method 1
the processing comprises one or more manufacturing methods capable of increasing vapor pressure of the one or more volatile lipophilic compounds when the one or more volatile lipophilic compounds are not combined with the one or more water-insoluble components
Implementation Method 2
adding one or more surface-active agents and one or more water-soluble components to the mixture; and emulsifying the mixture comprising the one or more surface-active agents and the one or more water-soluble components to provide an emulsion
Data Source
AI summary
Compositions and dosage forms that contain volatile lipophilic compounds, and methods of manufacturing such compositions and dosage forms, are described.