Volatile Insecticide Cyclodextrin Complex for Long-Term Stability

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Solution Overview

Problem

Conventional insecticidal compositions with volatile active ingredients face challenges in maintaining long-term effectiveness due to chemical-physical properties, particularly on porous and alkaline surfaces, and are affected by temperature, UV, and rain, leading to short-term pest control efficacy.

Innovation Solution

An aqueous composition combining at least one insecticide with a vapor pressure of 0.001 mPa at 20°C, cyclodextrin, and a polymer dispersion, where the polymer dispersion is obtained by polymerizing a monomer mixture in the presence of a hydrocolloid, providing improved stability and prolonged release of the active ingredient.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If volatile insecticides are used in conventional formulations, then immediate pest control effectiveness is achieved, but long-term stability and duration of action are reduced

Engineering Contradiction:
Improveimmediate pest control effectivenessVSAvoidlong-term stability
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The volatile insecticide is nested within the cyclodextrin inclusion complex, where the insecticide molecule is encapsulated in the cyclodextrin cavity. This nested structure protects the volatile compound from rapid evaporation while allowing controlled release, thereby extending duration of action without sacrificing immediate effectiveness

Inventive Principle:
Principle #7Nested doll (Nesting)

Solution Approach 2:

Cyclodextrin acts as an intermediary substance between the volatile insecticide and the environment. It mediates the release of the active ingredient, controlling evaporation rate and providing sustained availability while maintaining the insecticide's biological activity

Inventive Principle:
Principle #24Intermediary (Mediator)

2Area of stationary object

If spray coating is applied to porous and alkaline surfaces, then surface coverage is achieved, but effectiveness duration is severely impaired

Engineering Contradiction:
Improvesurface coverageVSAvoideffectiveness duration
Core Design Contradiction:
Area of stationary objectVSDuration of action of stationary object

Solution Approach 1:

The formulation creates a composite system combining cyclodextrin inclusion complexes with polymer dispersion and aqueous carriers. This composite material adheres to porous and alkaline surfaces while the cyclodextrin complex protects the insecticide from degradation, maintaining effectiveness duration despite surface challenges

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The cyclodextrin inclusion complex changes the physical-chemical parameters of the insecticide, reducing its volatility and improving its adhesion properties. This parameter modification allows the formulation to maintain effectiveness on porous and alkaline surfaces where conventional formulations fail

Inventive Principle:
Principle #35Parameter changes

3Reliability

If conventional formulations are exposed to environmental factors (temperature, UV, rain), then initial pest control is achieved, but active ingredient effectiveness is quickly lost

Engineering Contradiction:
Improveinitial pest controlVSAvoidactive ingredient stability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The cyclodextrin inclusion complex provides beforehand cushioning protection to the volatile insecticide against environmental stressors. The complex structure shields the active ingredient from temperature fluctuations, UV radiation, and rain, preventing premature degradation while maintaining initial pest control effectiveness

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Solution Approach 2:

Cyclodextrin serves as a protective intermediary between the insecticide and environmental factors. It mediates the interaction by absorbing environmental stress and releasing it gradually, protecting the active ingredient from direct exposure to temperature, UV, and moisture while sustaining its effectiveness

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves enhanced long-term biological activity, improved knock-down and mortality of insects, and increased durability against environmental influences like temperature, UV, and rain, with excellent chemical stability and compatibility with various surfaces.

Implementation Method 1

SAENGER was able to show that cyclodextrins can be used to bind highly volatile substances... Inclusion complexes of allethrin, resmethrin and pyrethrins in β-cyclodextrin are described

Methodology Applied
Scientific EffectInclusion complexation: Solvation

Implementation Method 2

SCENE et al. were able to show that volatile insecticides can be complexed with (β-cyclodextrin... The complexation of an active ingredient with cyclodextrin could also lead to a delayed or prolonged release

Methodology Applied
Scientific EffectControlled release: Diffusion

Data Source

PatentEP3462877B1Formulations comprising volatile insecticides with improved long-term stability and activity
Publication Date: 2020.11.18 BAYER CROPSCIENCE AG

AI summary

The invention relates to aqueous compositions containing volatile insecticides, which have improved long term stability and are therefore also biologically active for a longer period. The invention also relates to the use of such formulations for lasting control of animal pests (arthropods) on different surfaces.