Volumetric Phase-Error Correction for 4DPC MRI

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Solution Overview

Problem

Current methods for correcting phase-offset errors in volumetric phase-contrast MRI data are limited by their reliance on two-dimensional models, which are not consistently accurate across multiple planes and require significant manual intervention or increased acquisition time, making them impractical for clinical use.

Innovation Solution

A software program that enables user-guided selection of static tissue and exclusion of spatially-wrapped voxels, using a volumetric phase-error model to accurately correct phase-offsets across a three-dimensional imaging volume, allowing for dynamic model selection based on computational resources and field of view.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If two-dimensional phase-error correction models are used, then correction can be performed with existing methods, but accuracy is insufficient across multiple planes and requires manual intervention

Engineering Contradiction:
Improvephase-error correction accuracyVSAvoidmanual intervention requirement
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent transitions from two-dimensional phase-error correction models to three-dimensional volumetric models. This dimensional upgrade allows the correction to be applied consistently across multiple planes simultaneously, eliminating the need for separate manual corrections in each plane while maintaining or improving accuracy throughout the entire volume.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The volumetric phase-error model serves multiple planes and regions simultaneously with a single unified correction approach. This universal model replaces the need for plane-specific manual interventions, making the correction process both more accurate and easier to operate.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Ease of operation

If manual subtraction of velocities from stationary tissue is used, then correction is easy to perform, but it does not completely account for spatial dependence of phase-error

Engineering Contradiction:
Improvecorrection easeVSAvoidphase-error correction completeness
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

By moving from two-dimensional manual velocity subtraction to three-dimensional volumetric modeling, the system automatically captures spatial dependencies in all directions. The volumetric model inherently accounts for spatial variation throughout the entire volume without requiring manual selection of stationary tissue regions.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The volumetric phase-error model automatically identifies and corrects phase errors throughout the volume without requiring manual intervention to select stationary tissue. The system self-adjusts to account for spatial dependencies by utilizing the full three-dimensional data structure.

Inventive Principle:
Principle #25Self-service

3Reliability

If separate phase-error models are created for each slice and time-point, then correction can be applied locally, but consistency is lost and computational complexity increases

Engineering Contradiction:
Improvecorrection consistencyVSAvoidmodel complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges separate slice-by-slice and time-point-specific phase-error models into a single unified volumetric model. This consolidation ensures consistency across all planes and time-points while reducing the overall computational complexity by eliminating the need to manage multiple separate models.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

A single volumetric phase-error model serves all slices and time-points simultaneously, providing consistent correction throughout the entire four-dimensional dataset. This universal approach replaces the complex framework of multiple separate models with one cohesive solution.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP2729066B1Comprehensive cardiovascular analysis with volumetric phase-contrast MRI
Publication Date: 2021.01.27 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
  • EP2729066B1 patent drawingFigure 1A
  • EP2729066B1 patent drawingFigure 1B
  • EP2729066B1 patent drawingFigure 2A

AI summary

Processing techniques of volumetric anatomic and vector field data from volumetric phase-contrast MRI on a magnetic resonance imaging (MRI) system are provided to evaluate the physiology of the heart and vessels. This method includes the steps of: (1) correcting for phase-error in the source data, (2) visualizing the vector field superimposed on the anatomic data, (3) using this visualization to select and view planes in the volume, and (4) using these planes to delineate the boundaries of the heart and vessels so that measurements of the heart and vessels can be accurately obtained.