Antioxidant Ganoderma Lucidum Extract Processing Without Organic Solvents

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Solution Overview

Problem

Existing methods for preparing Ganoderma lucidum extract are complex, costly, and difficult to scale due to the use of organic solvents, leading to impurities and instability, limiting its application in foods and cosmetics.

Innovation Solution

A method involving hot water extraction, coarse filtration, centrifugation, micro-filtration using a ceramic membrane, and concentration to produce a high-activity Ganoderma lucidum extract without organic solvents, suitable for large-scale production.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If organic solvent extraction is used to obtain Ganoderma lucidum extract, then solubility is improved, but the preparation process becomes complex and costly with difficulty in removing impurities

Engineering Contradiction:
ImprovesolubilityVSAvoidpreparation process complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent extracts only the necessary active components from Ganoderma lucidum using water extraction, removing the need for complex organic solvent extraction processes. This takes out the harmful organic solvents while retaining the essential polysaccharides and other active ingredients, simplifying the preparation process while maintaining extract stability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the extraction parameter from organic solvents to water, and optimizes extraction temperature and time parameters. This parameter change eliminates the need for multiple solvent systems while achieving effective extraction of active components, reducing process complexity and impurity formation

Inventive Principle:
Principle #35Parameter changes

2Ease of manufacture

If simple screen filtering is used for water extraction, then the preparation process is simplified, but the extract becomes unstable with precipitation and poor clarity

Engineering Contradiction:
Improvepreparation process simplicityVSAvoidextract stability
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent segments the filtration process into multiple stages: coarse filtration to remove large particles, followed by fine filtration to remove smaller impurities. This segmentation allows each filtration stage to target specific particle sizes, achieving both process simplicity and extract stability without requiring complex single-step filtration

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent performs preliminary actions including soaking the Ganoderma lucidum material before extraction, and conducting extraction at optimized temperature and time conditions. These preliminary actions prepare the material for easier filtration and prevent precipitation during storage, maintaining extract stability while keeping the process simple

Inventive Principle:
Principle #10Preliminary action

3Stability of the object's composition

If multiple extraction steps with different solvents are used, then solubility is improved, but the cost increases and large scale production becomes difficult

Engineering Contradiction:
Improveextract solubilityVSAvoidlarge scale production capability
Core Design Contradiction:
Stability of the object's compositionVSProductivity

Solution Approach 1:

The patent makes water serve multiple functions: as extraction solvent, as purification medium, and as the final product base. This multi-functionality eliminates the need for multiple different solvents (petroleum ether, ethanol, chloroform, ethyl acetate), reducing cost and simplifying the process for large-scale production while maintaining extract solubility through optimized water extraction parameters

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method achieves a high polysaccharide content extract with improved clarity and reduced impurities, suitable for large-scale industrial production and applications in foods and cosmetics.

Implementation Method 1

mixing the crushed fruit body of Ganoderma lucidum with pure water, heating, stirring and extracting to obtain a crude extract

Methodology Applied
Scientific EffectDissolution: Solvation

Implementation Method 2

heating, stirring and extracting to obtain a crude extract

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 3

the crude filtration obtained in step (2) is subject to secondary impurity removal by using a disc stack centrifuge to obtain filtrate

Methodology Applied
Scientific EffectCentrifugal separation: Centrifugal Separation

Implementation Method 4

the filtrate obtained in step (3) is filtered by a ceramic membrane with the aperture of 400 ̃1200 nm, and the permeate is collected

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Implementation Method 5

concentrating and drying the permeate in step (4) to obtain the antioxidant repair Ganoderma lucidum extract

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS20250319146A1Anti-Oxidant Repair Ganoderma Lucidum Extract and Preparation Method Therefor
Publication Date: 2025.10.16 GUANGDONG YUEWEI EDIBLE FUNGI TECH
  • US20250319146A1 patent drawing
  • US20250319146A1 patent drawing
  • US20250319146A1 patent drawing

AI summary

The present invention relates to the technical field of preparation of food and cosmetic raw materials. Disclosed are an antioxidant repair Ganoderma lucidum extract and a preparation method therefor. The preparation method comprises: mixing crushed fruit body of Ganoderma lucidum with pure water, and heating and dynamically extracting to obtain a crude extract; standing the obtained crude extract, naturally settling, filtering a supernatant by using a screen mesh, and collecting a crude filtrate; using a disc stack centrifuge to perform secondary impurity removal on the obtained crude filtrate so as to obtain a filtrate; performing fine filtration by using a ceramic membrane having a pore diameter of 400-1200 nm, and collecting a permeate; and finally, concentrating and drying to obtain an antioxidant repair Ganoderma lucidum extract. The preparation method of the present invention is simple to operate and low in cost, and has the advantage of large scale. The finished product is high in controllability and stability, and the Ganoderma lucidum extract which is wide in application and good in effect can be provided for the industries of food, health food, and cosmetics.