Water-Free Antimicrobial Composition Without C2-C5 Alcohols

Solution Overview

Problem

Existing antimicrobial compositions for skin disinfection often contain water and C2-C5 alcohols, which can cause skin irritation and require higher concentrations of antimicrobial agents, leading to potential resistance and increased production costs.

Innovation Solution

An antimicrobial composition comprising 60 wt. % to 99.4 wt. % solubilizer, 0.1 wt. % to 10 wt. % antimicrobial agent, and 0.1 wt. % to 15 wt. % cidatrope, substantially free of water and C2-C5 alcohols, enhancing antimicrobial activity through synergistic effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If water and C2-C5 alcohols are used in antimicrobial compositions, then the compositions can be formulated with higher antimicrobial agent concentrations, but skin irritation increases and production costs increase

Engineering Contradiction:

Improveantimicrobial agent concentrationVSAvoidskin irritation

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by eliminating water and C2-C5 alcohols from the formulation, replacing them with alternative solubilizers and cidatropes. This parameter change allows maintaining antimicrobial efficacy while reducing skin irritation and production costs.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite antimicrobial composition combining specific solubilizers (60-99.4 wt%), antimicrobial agents (0.1-10 wt%), and cidatropes (0.1-15 wt%) in a water-free, alcohol-free matrix. This composite formulation achieves synergistic effects that maintain efficacy while reducing harmful effects.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If water and C2-C5 alcohols are used in antimicrobial compositions, then the compositions can be formulated with higher antimicrobial agent concentrations, but production costs increase

Engineering Contradiction:

Improveantimicrobial agent concentrationVSAvoidproduction cost

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

The patent changes the chemical composition parameters by eliminating water and C2-C5 alcohols from the formulation, replacing them with alternative solubilizers and cidatropes. This parameter change allows maintaining antimicrobial efficacy while reducing skin irritation and production costs.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite antimicrobial composition combining specific solubilizers (60-99.4 wt%), antimicrobial agents (0.1-10 wt%), and cidatropes (0.1-15 wt%) in a water-free, alcohol-free matrix. This composite formulation achieves synergistic effects that maintain efficacy while reducing harmful effects.

Inventive Principle:

Principle #40Composite materials

3Reliability

If higher concentrations of antimicrobial agents are used, then antimicrobial activity increases, but resistance development increases

Engineering Contradiction:

Improveantimicrobial activityVSAvoidresistance development

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent creates a composite antimicrobial composition combining specific solubilizers (60-99.4 wt%), antimicrobial agents (0.1-10 wt%), and cidatropes (0.1-15 wt%) in a water-free, alcohol-free matrix. This composite formulation achieves synergistic effects that maintain efficacy while reducing harmful effects.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the chemical composition parameters by eliminating water and C2-C5 alcohols from the formulation, replacing them with alternative solubilizers and cidatropes. This parameter change allows maintaining antimicrobial efficacy while reducing skin irritation and production costs.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides rapid and persistent antimicrobial activity with lower agent concentrations, reducing skin irritation and production costs while minimizing resistance development.

Implementation Method 1

an antimicrobial composition comprising 60 wt. % to 99.4 wt. % solubilizer, 0.1 wt. % to 10 wt. % antimicrobial agent and 0.1 wt. % to 15 wt. % cidatrope

Methodology Applied

Scientific EffectSolubilization: Solvation

Implementation Method 2

a cidatrope, where the compositions are substantially free of water and C2-C5 alcohols... enhancing antimicrobial activity through synergistic effects

Methodology Applied

Scientific EffectSynergistic effect:

Data Source

PatentUS12419823B2Antimicrobial composition

Publication Date: 2025.09.23 SOLVENTUM INTELLECTUAL PROPERTIES CO

AI summary

Antimicrobial compositions containing an antimicrobial agent, such as an octenidine salt, a solubilizer, such as a glycol, and a cidatrope, such as a C8-C26 alcohol, an ether, an amide, an ester, and combinations thereof, where the compositions are substantially free of water and C2-C5 alcohols and methods of making such antimicrobial compositions.