Water-Soluble Cannabinoid Composition for Higher Bioavailability
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Solution Overview
Problem
Current methods of administering cannabinoids fail to take full advantage of their properties, lack control over selecting individual cannabinoids, introduce harmful compounds, and have low bioavailability and permeability into the bloodstream.
Innovation Solution
Development of water soluble cannabinoid formulations using purified cannabinoids and Vitamin E TPGS, formulated with other compounds to enhance solubility and bioavailability, and optionally with carrier oils to improve stability and onset.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If cannabinoids are extracted as crude mixture from cannabis plant, then extraction process is simple, but bioavailability and permeability into bloodstream are low
Solution Approach 1:
The patent extracts and isolates specific cannabinoids (such as CBD, THC, CBG) from the crude cannabis extract through chromatography and other purification methods. This selective extraction removes unwanted compounds while concentrating the desired cannabinoids, thereby improving bioavailability and permeability while maintaining a streamlined process through automated purification systems.
Solution Approach 2:
The patent creates composite formulations by combining purified cannabinoids with carrier molecules such as phospholipids, proteins, or synthetic carriers that enhance solubility and permeability. These composite structures improve the bioavailability of cannabinoids without significantly complicating the manufacturing process, as the carrier molecules can be incorporated during the formulation stage.
2Ease of operation
If plant matter is burned and vapor inhaled, then administration method is simple, but harmful and toxic compounds are introduced into the body
Solution Approach 1:
The patent extracts and removes harmful combustion byproducts and toxic compounds from the cannabis plant material through purification processes. By isolating the desired cannabinoids from the crude extract and eliminating carcinogens and toxins, the formulation provides a safe alternative to combustion while maintaining ease of administration through various delivery methods such as oral, sublingual, or inhalation of vaporized purified extract.
Solution Approach 2:
The patent changes the physical and chemical parameters of cannabinoid delivery by formulating purified cannabinoids in various carriers and delivery systems. This allows administration through multiple routes (oral, sublingual, inhalation) without combustion, thereby eliminating toxic compounds while preserving the simplicity of administration. The purified formulations can be delivered as tinctures, capsules, or vaporized extracts.
3Reliability
If purified cannabinoids are formulated with carriers to enhance solubility, then bioavailability increases, but formulation complexity increases
Solution Approach 1:
The patent uses carrier molecules as intermediaries to bridge the gap between hydrophobic cannabinoids and aqueous biological environments. Phospholipids, proteins, and synthetic carriers act as mediators that solubilize cannabinoids and facilitate their transport across biological membranes. These intermediaries are incorporated into the formulation process through standardized protocols, managing complexity while significantly improving bioavailability.
Solution Approach 2:
The patent optimizes formulation parameters such as carrier-to-cannabinoid ratios, pH levels, and temperature conditions to enhance solubility and bioavailability. By systematically adjusting these parameters and establishing standardized formulation protocols, the patent improves bioavailability while controlling formulation complexity through methodical optimization rather than trial-and-error approaches.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides increased bioavailability and permeability of cannabinoids into the bloodstream, offering stable, calorie-free, and natural formulations suitable for various liquid and solid applications.
Implementation Method 1
formulated with other compounds to enhance solubility
Implementation Method 2
Vitamin E TPGS
Implementation Method 3
Provides increased bioavailability and permeability of cannabinoids into the bloodstream
Data Source
AI summary
This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heating material to a first temperature and a second temperature.