Water-Soluble Fluorescent Compound via Photochemical Reaction
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Solution Overview
Problem
There is a need for a water-soluble fluorescent compound with high single-photon and two-photon absorptive characteristics that can be efficiently prepared and used in various applications without toxicity.
Innovation Solution
A water-soluble fluorescent compound represented by specific formulas, derived from glycosylated resveratrol derivatives, is prepared through a photochemical reaction under UV irradiation, maintaining water solubility and exhibiting excellent fluorescent characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional fluorescent compounds are used, then fluorescent characteristics can be achieved, but water solubility is poor
Solution Approach 1:
The patent combines a fluorescent core structure with water-soluble substituent groups (such as hydroxyl, carboxyl, or amino groups) to create a composite molecular structure that simultaneously provides fluorescent properties and water solubility. This allows the compound to function as both a fluorescent marker and a water-soluble substance for biological applications.
Solution Approach 2:
The patent introduces water-soluble functional groups at specific positions on the molecular structure while maintaining the core fluorescent system intact. This localized modification ensures that the fluorescent characteristics are preserved while adding the desired water solubility property to specific regions of the molecule.
2Ease of manufacture
If single-photon absorption fluorescent substances are used, then simple excitation can be achieved, but two-photon absorption efficiency is insufficient for deep tissue imaging
Solution Approach 1:
The patent modifies the molecular structure to optimize two-photon absorption cross-section by changing electronic parameters such as HOMO-LUMO energy gaps and electron delocalization. This allows the compound to efficiently absorb two photons simultaneously, enabling deep tissue imaging while maintaining reasonable excitation conditions.
3Reliability
If fluorescent compounds with high absorptive efficiency are developed, then imaging quality improves, but toxicity may increase
Solution Approach 1:
The patent optimizes the molecular structure to achieve high absorptive efficiency through controlled electron delocalization and appropriate HOMO-LUMO energy gaps, while simultaneously selecting biocompatible functional groups and molecular configurations that minimize toxicity. This balanced optimization allows high-performance fluorescent imaging with reduced biological harm.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting compound has high efficiency in single-photon and two-photon absorptive characteristics, is non-toxic, and can be used in applications such as sunblocks, diagnostics, and display elements, offering advantages in fields requiring water-soluble fluorescent materials.
Implementation Method 1
a single-photon absorption fluorescent substance which absorbs only one photon under a strong laser to emit the fluorescence
Implementation Method 2
a multi-photon absorption fluorescent substance which absorbs a plurality of photons to emits the fluorescence. The present invention relates to a new water-soluble fluorescent compound simultaneously having a single-photon absorption fluorescent feature as well as a multi-photon absorption fluorescent feature, in particular, 2-photon absorption fluorescent feature
Implementation Method 3
Fluorescence refers to the phenomenon that a substance emits light only when the substance is irradiated
Implementation Method 4
after a photochemical reaction of a conventionally known glycosylated derivative of resveratrol, for example, polydatin
Data Source
AI summary
The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-β-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Formula I which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-β-glucoside and its derivatives of having Formula 3 which are not fluorescent.Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).