Weighted Hypoxemia Index for Standardized Health Risk Prediction
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Solution Overview
Problem
Current methods lack a standardized approach to quantify and compare hypoxemia across different clinical contexts, leading to inadequate assessment of its severity and consequences, which can result in adverse health outcomes and increased mortality.
Innovation Solution
A method and system for determining a weighted hypoxemia index by analyzing biological signals, identifying events based on threshold crossings, calculating areas under and above the threshold, applying weighted factors, and normalizing these values to derive a health metric, which can be used to assess health risks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If traditional hypoxemia measurement methods (SpO2, AHI, TST90, Min Sat) are used, then basic oxygen saturation data can be obtained, but there is no standardized method to quantify and compare hypoxemia severity across different clinical contexts
Solution Approach 1:
The patent transforms raw SpO2 time-series data into a standardized hypoxemia severity score by changing parameters through mathematical operations. It calculates area under the curve (AUC), area above the curve (AAC), applies weighted factors based on event characteristics, and normalizes results to produce a dimensionless severity metric that can be compared across different clinical scenarios.
Solution Approach 2:
The patent segments the hypoxemia assessment into distinct components: identifying individual hypoxemic events through threshold crossings, calculating AUC and AAC for each event, determining weighted factors based on event characteristics, and aggregating results. This segmentation allows systematic processing of complex time-series data into a unified severity metric.
2Measurement precision
If multiple existing metrics (AHI, TST90, Min Sat) are used to assess hypoxemia, then various aspects of oxygenation can be measured, but the consequences and severity of hypoxemia cannot be standardized compared
Solution Approach 1:
The patent creates a universal hypoxemia severity scoring system that can be applied across multiple clinical contexts (sedation-related, postoperative, exercise-induced, nocturnal hypoxemia, etc.). The same algorithm processes different types of hypoxemic events and produces comparable severity scores, making the system multi-functional and adaptable to various scenarios.
Solution Approach 2:
The patent incorporates feedback mechanisms through weighted factors that adjust the severity score based on event characteristics such as duration, depth, and frequency of hypoxemia. This feedback loop ensures that the severity assessment reflects the actual clinical impact of different hypoxemic patterns.
3Productivity
If simple threshold-based metrics (AHI counting events below 90%) are used, then calculation is straightforward, but the temporal dimension and severity of hypoxemia during sleep are not reflected
Solution Approach 1:
The patent adds temporal and severity dimensions to the basic threshold-based counting approach. Instead of merely counting events, it calculates the area under the curve (AUC) and area above the curve (AAC) for each event, incorporating duration and depth of hypoxemia. This transforms a one-dimensional count into a multi-dimensional severity assessment that captures temporal characteristics.
Data Source
AI summary
Methods, systems, and apparatuses for determining a health metric and one or more health risks based on one or more biological events. Data indicative of one or more biological events may be determined based on a biological signal associated with an individual and a weighted factor may be determined for each biological event. The weighted factor may be applied to each biological event to determine one or more weighted biological events. A health metric may be determined based on the one or more weighted biological events. The health metric may be used to determine one or more health risks associated with the individual, wherein the individual may be treated based on the one or more health risks.