Wet-Laid Label Substrate for Rapid Lateral Flow Assays
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Solution Overview
Problem
Existing lateral flow assay techniques face challenges in achieving rapid detection with high sensitivity due to limitations in label release from substrates, such as glass fibers and non-woven fabrics, which lack sufficient tensile strength, basis weight uniformity, and connectivity to membranes.
Innovation Solution
The use of a wet-laid non-woven fabric, particularly made of polyester fibers, with smooth surfaces and specific properties, enhances connectivity to membranes and improves label release efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If glass fiber or conventional non-woven fabric is used as substrate in label area, then label release ability is sufficient, but tensile strength is insufficient and basis weight uniformity is poor
Solution Approach 1:
The patent changes the physical and chemical parameters of the substrate by specifying a basis weight of 10-200 g/m² and using wet-laid non-woven fabric with specific fiber composition, transforming the substrate properties to simultaneously achieve sufficient tensile strength and improved basis weight uniformity for stable label release
Solution Approach 2:
The patent uses composite material structure by combining wet-laid non-woven fabric with specific fiber types and properties, creating a substrate that integrates both mechanical strength and manufacturing precision requirements in a single material system
2Strength
If conventional non-woven fabric is used as substrate, then tensile strength is improved, but connectivity to membrane is poor and label release is insufficient
Solution Approach 1:
The patent optimizes substrate parameters by specifying basis weight of 10-200 g/m² and using wet-laid non-woven fabric with controlled fiber composition, achieving both adequate tensile strength and reliable label release through precise parameter control
Solution Approach 2:
The patent applies local quality principle by specifying that the label area substrate has particular properties (basis weight 10-200 g/m², wet-laid non-woven fabric) that are optimized specifically for label release, while other areas of the test strip can have different properties suited to their functions
3Stability of the object's composition
If label is dried on substrate, then label is stable, but label release is slow and detection time is extended
Solution Approach 1:
The patent changes the substrate parameters (basis weight 10-200 g/m², wet-laid structure) to optimize the interaction between dried label and substrate, enabling rapid label release while maintaining label stability during storage and transport
Solution Approach 2:
The patent performs preliminary action by pre-optimizing the substrate properties before label application, ensuring that the substrate is pre-configured with appropriate basis weight and structure to enable rapid label release when needed, without requiring additional processing steps
Data Source
Figure 1A~1B
AI summary
This invention provides a test strip for lateral flow assay that enables an assay within a short period of time with high sensitivity with the use of a substrate that is excellent in connectivity to a membrane and sufficiently releases labels in a label area. The test strip for lateral flow assay used to detect or quantify an analyte comprises at least a support plate, a sample supply area, a label area including a label that binds to an analyte, and a developing area provided with a detection area including a capture material that binds to the analyte, wherein a substrate of the label area is made of a wet-laid non-woven fabric.