Granular Wheat Middlings Carrier Flowability

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Solution Overview

Problem

Therapeutic compositions, such as nicarbazin formulations, often exhibit poor flowability issues due to their powdery or flaky nature, leading to problems like 'surge flow' and 'bridge over' during conveyance and pouring, which existing methods like agitation have not successfully addressed.

Innovation Solution

A composition comprising processed granular wheat middlings with a size of 20 mesh to 80 mesh, combined with soybean oil and micro tracers, which improves the flowability characteristics without affecting the efficacy of the therapeutic agent, achieving a composite flow index 30% to 200% greater than non-processed formulations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If powdered or flakey wheat middlings are used in therapeutic compositions, then the composition can be easily manufactured and stored, but the composition exhibits poor flowability causing surge flow and bridge over during conveyance and pouring

Engineering Contradiction:

Improveease of manufactureVSAvoidflowability

Core Design Contradiction:

Ease of manufactureVSEase of operation

Solution Approach 1:

The patent changes the physical parameters of the wheat middlings by controlling particle size (20-80 mesh) and moisture content (10-30%), transforming it from poor flowability to improved flowability while maintaining ease of manufacture

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite formulation combining treated wheat middlings with therapeutic agents and excipients, where the processed carrier material provides improved flow characteristics that benefit the entire composition

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If agitation methods are used to improve flowability, then some flow improvement may be achieved, but the method is complex and does not successfully address the flowability problems

Engineering Contradiction:

ImproveflowabilityVSAvoiddevice complexity

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by pre-processing the wheat middlings (granulation, drying, size reduction to 20-80 mesh) before formulation, so that the material has improved flowability built-in from the start, eliminating the need for complex agitation devices

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS11554119B2Composition having improved flowabilty and methods for making and using the composition

Publication Date: 2023.01.17 PHIBRO ANIMAL HEALTH CORP

AI summary

Disclosed compositions comprise a therapeutic agent and a carrier selected, or processed to have, an acceptable composite flow index, a granular particle size of 18 mesh to 80 mesh, or both, such as processed granular wheat middlings. The composition may also comprise an oil and/or micro tracers. Suitable granular wheat middlings may have a size range of from 18 mesh to 80 mesh, such as 20 mesh to 80 mesh. The composition has improved flowability characteristics, compared to a composition where the carrier, such as processed wheat middlings, are powdered and/or flakey. Certain embodiments concern a composition comprising, consisting essentially of, or consisting of, nicarbazin, granular wheat middlings, soybean oil and micro tracers. The composition may be administered to an animal, for example, to treat or prevent coccidiosis. Also disclosed herein are methods for making and using the composition.