Whey Fermentation and Reverse Osmosis for Ethanol-Galactose Separation

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Solution Overview

Problem

Current ethanol production methods rely on grain carbohydrate sources and energy-intensive processes like distillation and pervaporation, which are costly and limit the utilization of galactose sugars into commercial products.

Innovation Solution

A fermentation process using a lactose substrate, such as dairy whey, enzymatically converts lactose into glucose and galactose, followed by yeast fermentation and reverse osmosis to separate ethanol and galactose without distillation or pervaporation, producing high ethanol and galactose compositions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If distillation or pervaporation is used to separate ethanol from fermentation broth, then ethanol concentration is improved, but energy consumption increases and the product cannot be classed as a fermentate

Engineering Contradiction:
Improveethanol concentrationVSAvoidenergy consumption
Core Design Contradiction:
Quantity of substanceVSUse of energy by moving object

Solution Approach 1:

The patent changes the separation mechanism from thermal-based (distillation/pervaporation) to pressure-based reverse osmosis. By using RO membranes with specific pore sizes and operating at lower pressures, the system achieves ethanol concentration without phase change, thereby reducing energy consumption while maintaining fermentate classification.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent replaces the thermal-mechanical separation systems (distillation columns, pervaporation units) with a membrane-based mechanical separation system (reverse osmosis). This substitution eliminates the need for heating and phase change, directly addressing the energy consumption issue while producing high-concentration ethanol permeate.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Productivity

If grain carbohydrate sources are used for ethanol production, then fermentation efficiency is improved, but the process requires energy-intensive distillation and does not utilize galactose sugars

Engineering Contradiction:
Improvefermentation efficiencyVSAvoidenergy-intensive processing
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

The patent uses lactose-containing substrates (like whey) that provide both glucose and galactose. The fermentation process converts glucose to ethanol while galactose remains in the retentate for separate valorization. This multi-functional approach simultaneously produces ethanol and creates a valuable galactose product stream, eliminating waste and reducing the need for grain-based substrates.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

Instead of discarding galactose as a byproduct (as in conventional lactose fermentation), the patent recovers and concentrates it in the retentate stream. This recovery approach transforms a waste product into a valuable commodity, improving overall process efficiency and reducing energy requirements compared to distilling the entire fermentation broth.

Inventive Principle:
Principle #34Discarding and recovering

3Manufacturing precision

If pervaporation is used to separate galactose from ethanol, then separation is achieved, but the process is energy intensive and requires constant membrane cleaning and replacement

Engineering Contradiction:
Improveseparation purityVSAvoidmembrane maintenance complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

Instead of using pervaporation to separate galactose from ethanol (as in prior art), the patent inverts the approach by using reverse osmosis to separate the ethanol-containing small molecules from the galactose-containing larger molecules. This inversion places galactose in the retentate and ethanol in the permeate, achieving separation without the drawbacks of pervaporation membranes.

Inventive Principle:
Principle #13The other way round (Inversion)

Solution Approach 2:

The patent employs reverse osmosis membranes that are more robust and easier to maintain than pervaporation membranes. These RO membranes can handle the fermentation broth conditions better and do not require constant cleaning and replacement, reducing device complexity and operational costs while achieving the necessary separation purity.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method efficiently produces ethanol and galactose without grain-based substrates and energy-intensive processes, achieving high ethanol concentrations up to 25% ABV and galactose enrichment, suitable for commercial use.

Implementation Method 1

treating the lactose containing substrate with an enzyme (e.g. a beta-galactosidase enzyme) to provide an enzyme treated substrate in which at least some of the lactose in the substrate has been enzymatically converted into glucose and galactose

Methodology Applied
Scientific EffectEnzymatic hydrolysis: Hydrolysis

Implementation Method 2

fermenting in a fermentation medium comprising the enzyme-treated substrate a glucose fermenting yeast to provide a fermentation broth containing ethanol and galactose

Methodology Applied
Scientific EffectFermentation: Fermentation

Implementation Method 3

The fermentation broth is then separated by a suitable separation technology such as reverse osmosis to remove the ethanol from the fermentation broth leaving behind a galactose rich composition

Methodology Applied
Scientific EffectReverse osmosis: Reverse Osmosis

Data Source

PatentUS20260078418A1A method of making an ethanol composition and a separate galactose composition by fermentation
Publication Date: 2026.03.19 WEST CORK DISTILLERS
  • US20260078418A1 patent drawing

AI summary

A method of making an ethanol composition and a separate galactose composition by fermentation is described. The method does not require wheat substrates and does not require a distillation step to separate out the ethanol. The methods comprises treating the lactose containing substrate with a beta-galactosidase enzyme to provide an enzyme treated substrate in which at least some of the lactose in the substrate has been enzymatically converted into glucose and galactose, fermenting in a fermentation medium comprising the enzyme-treated substrate a glucose fermenting yeast to provide a fermentation broth containing ethanol and galactose, and separating the fermentation broth into an ethanol composition and a separate galactose composition. The fermentation broth is generally separated by reverse osmosis into a retentate and a permeate, in which the permeate is the ethanol composition and the retentate is the galactose composition.