Whey-Leucine Omega-3 Composition for Cancer Cachexia Muscle Function

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing nutritional compositions fail to effectively address muscle wasting and functional decline in cancer patients, particularly due to cancer cachexia, by not adequately combining protein sources like whey protein with leucine and ω-3 polyunsaturated fatty acids to enhance muscle function and overall quality of life.

Innovation Solution

A nutritional composition comprising at least 18 en% proteinaceous matter with whey protein, at least 12 wt% leucine, and ω-3 polyunsaturated fatty acids, such as eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid, or docosapentaenoic acid, designed to improve muscle function and daily activities in mammals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional nutritional compositions are used, then caloric intake is provided, but muscle function is not effectively improved due to inadequate combination of protein sources with leucine and ω-3 polyunsaturated fatty acids

Engineering Contradiction:
Improveeffectiveness in addressing muscle wastingVSAvoidcomplexity of nutritional composition
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines whey protein, leucine, and ω-3 polyunsaturated fatty acids into a single nutritional composition. This merging of multiple beneficial components into one formulation allows the composition to effectively address muscle wasting and functional decline while maintaining ease of use and administration.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The nutritional composition functions as a composite material combining different nutritional components (whey protein, leucine, and ω-3 polyunsaturated fatty acids) that work synergistically. Each component contributes specific properties: whey protein provides essential amino acids, leucine stimulates protein synthesis, and ω-3 fatty acids reduce inflammation, together creating a formulation more effective than individual components alone.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If protein supplementation is increased to counteract net body protein breakdown, then muscle protein synthesis may improve, but the catabolic signal remains unmitigated without additional components

Engineering Contradiction:
Improveprotein supplyVSAvoidcatabolic signal
Core Design Contradiction:
Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful catabolic signal into a beneficial outcome by combining protein supplementation with ω-3 polyunsaturated fatty acids. The ω-3 fatty acids mitigate the catabolic signal and reduce inflammation, thereby converting the potentially harmful protein breakdown process into a net anabolic effect when combined with adequate protein intake.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent changes the nutritional parameters by not only increasing protein quantity but also adding specific components (leucine and ω-3 polyunsaturated fatty acids) that modify the metabolic response. This multi-parameter approach ensures both adequate substrate availability and optimization of the anabolic/catabolic balance.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentEP3906788B1Nutritional composition for providing a better prognosis in terms of extended life-expectancy
Publication Date: 2026.04.01 NV NUTRICIA
  • EP3906788B1 patent drawingFigure 1A~1B
  • EP3906788B1 patent drawingFigure 2A~2B
  • EP3906788B1 patent drawingFigure 2C~2D

AI summary

The invention relates to a nutritional composition comprising (a) at least 18 en% of proteinaceous matter, said proteinaceous matter comprising whey; (b) at least 12 wt% of leucine, based on total proteinaceous matter; and (c) a lipid fraction comprising at least a ω-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid for improving the muscle function in a mammal, for improving daily activity, for improving physical performance, for providing a better prognosis in terms of extended life-expectancy, for improving compliance to an anti-cancer therapy or for improving a quality of life.