Whole Blood Coagulation Analysis via Dielectric Measurement
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Solution Overview
Problem
Current blood coagulation tests lack sensitivity to detect deficiencies in extrinsic or intrinsic coagulation factors, which is crucial for conditions like hemophilia and during surgeries involving heart-lung machines, and are time-consuming due to the need for plasma separation.
Innovation Solution
A blood coagulation system analysis system that measures blood coagulation under both extrinsic and intrinsic system acceleration conditions, using a blood electrical measurement apparatus to extract coagulation parameters such as clot time and clot strength from dielectric constant changes, allowing for evaluation of coagulation factor levels and fibrinogen function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If plasma separation is performed to obtain plasma for coagulation tests, then test purity is improved, but test time and operational complexity increase
Solution Approach 1:
The invention extracts and removes the plasma separation step from the coagulation testing process. By using whole blood instead of separated plasma, the method eliminates the time-consuming centrifugation and plasma isolation procedures while maintaining reliable test results through direct measurement of coagulation parameters in the complete blood matrix.
Solution Approach 2:
The invention segments the testing approach by measuring coagulation parameters directly in whole blood components (platelets, red blood cells, plasma) without requiring integration into separated plasma. This allows parallel assessment of different blood components' contributions to coagulation, reducing overall test time while maintaining reliability.
2Measurement precision
If plasma separation is performed to obtain plasma for coagulation tests, then test accuracy is improved, but operational complexity increases
Solution Approach 1:
The invention extracts the plasma separation operation from the testing workflow. By designing the coagulation measurement system to work directly with whole blood, it removes the need for centrifuges, plasma separation protocols, and associated operational steps, thereby reducing operational complexity while preserving measurement precision through direct in-situ measurement.
Solution Approach 2:
The invention creates a universal testing approach where a single coagulation measurement system can analyze whole blood directly, eliminating the need for separate plasma preparation equipment and procedures. This multi-functional approach simplifies operational complexity by using one system for both whole blood handling and coagulation parameter measurement.
3Stability of the object's composition
If conventional coagulation tests are used, then standardization is maintained, but sensitivity to coagulation factor deficiencies is reduced
Solution Approach 1:
The invention applies local quality analysis by measuring coagulation parameters in different whole blood components (platelet-rich plasma, red blood cell-containing plasma) separately and analyzing their individual contributions. This localized measurement approach enhances sensitivity to specific coagulation factor deficiencies while maintaining overall test standardization through controlled measurement conditions.
Solution Approach 2:
The invention introduces dynamic measurement capabilities by monitoring coagulation parameter changes over time in whole blood samples. This dynamic approach allows detection of subtle changes in coagulation factor activity that static endpoint measurements miss, thereby improving sensitivity while maintaining standardization through time-resolved measurement protocols.
4Adaptability or versatility
If thromboelastography is used to monitor coagulation processes, then comprehensive monitoring is improved, but measurement sensitivity to coagulation factor deficiencies is reduced
Solution Approach 1:
The invention segments the comprehensive coagulation monitoring into distinct measurable parameters (clotting time, clot strength, fibrinogen levels, platelet function) that can be independently quantified from whole blood measurements. This segmented approach maintains comprehensive monitoring capability while improving sensitivity to specific coagulation factor deficiencies through parameter-specific analysis.
Solution Approach 2:
The invention utilizes parameter changes in whole blood coagulation measurements (changes in dielectric properties, viscosity, or optical characteristics during coagulation) to detect subtle deficiencies in coagulation factors. By monitoring multiple physical parameters simultaneously in whole blood, it achieves both comprehensive monitoring and high sensitivity to factor deficiencies.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system provides high sensitivity for detecting coagulation factor deficiencies and functional changes, enabling more accurate assessment of coagulation abilities, particularly in surgical settings, and reduces the time and effort required for testing.
Implementation Method 1
using a blood electrical measurement apparatus to extract coagulation parameters such as clot time and clot strength from dielectric constant changes
Data Source
AI summary
To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like.A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.