Whole Blood Coagulation Analysis via Complex Permittivity
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Solution Overview
Problem
Current blood coagulation tests, such as PT-INR and APTT, primarily evaluate bleeding risks associated with anticoagulant-induced hypocoagulability but fail to assess thrombus risks related to hypercoagulability, and existing platelet aggregability tests using PRP are cumbersome and inaccurate due to centrifugation activation issues.
Innovation Solution
A blood coagulation system analyzing method and device that measure complex permittivity spectra changes in response to platelet-activating or inactivating substances, allowing for the evaluation of both hypercoagulability and hypocoagulability using whole blood by analyzing changes in coagulation time and spectrum patterns.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional blood coagulation tests (PT-INR, APTT) are used, then bleeding risk evaluation is improved, but thrombus risk evaluation capability deteriorates
Solution Approach 1:
The complex permittivity spectrum measurement system is designed to evaluate multiple aspects of blood coagulability (both hypercoagulability and hypocoagulability) through a single measurement approach, making the testing method universal for assessing different thrombotic and hemorrhagic risks without requiring separate specialized tests
2Measurement precision
If PRP-based platelet aggregability test is used, then platelet function measurement is possible, but operation complexity increases due to centrifugation requirement
Solution Approach 1:
The invention extracts and measures the complex permittivity spectrum characteristics of whole blood that directly reflect platelet aggregation status, eliminating the need to extract or separate platelets through centrifugation. The measurement directly captures platelet aggregability information from intact whole blood samples
3Measurement precision
If PRP-based platelet aggregability test is used, then platelet function measurement is possible, but measurement accuracy deteriorates due to platelet activation during centrifugation
Solution Approach 1:
The invention performs measurement of complex permittivity spectrum on whole blood before any centrifugation or platelet activation procedures are initiated. By capturing the baseline electrical characteristics of platelets in their native state within intact blood, the system ensures accurate measurement of true platelet aggregability without artifacts from premature activation
4Adaptability or versatility
If complex permittivity spectrum measurement is used, then both hypercoagulability and hypocoagulability evaluation capability is improved, but device complexity increases
Solution Approach 1:
The invention replaces complex mechanical centrifugation systems and multiple separate measurement devices with an electrical measurement system that uses electrodes to measure complex permittivity spectrum. This substitution of mechanical procedures with electrical measurements simplifies the overall device architecture while expanding evaluation capabilities
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and efficient evaluation of platelet aggregability, facilitating drug efficacy assessment and risk management for thrombosis and bleeding tendencies in patients and healthy individuals at risk, particularly those taking anti-platelet aggregation or anticoagulant medications.
Implementation Method 1
a measuring section for measuring a permittivity of the blood; an analyzing section for analyzing a time change of the permittivity of the blood measured at a time interval after an effect of an anticoagulant on the blood is released
Data Source
AI summary
A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.