Withania Somnifera Extract Composition for Enhanced Bioavailability
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Solution Overview
Problem
There is a need for alternative Withania somnifera compositions with improved properties, as existing formulations may not fully leverage the bioactive potential of its constituents.
Innovation Solution
A novel Withania somnifera extract composition is developed, comprising a range of bioactive compounds such as withaferin A, withanoside IV, withanolide A, and others, which can be used in nutraceutical or pharmaceutical compositions, along with a detailed process for preparing the extract.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional extraction methods are used for Withania somnifera, then the extraction process is simple, but the bioavailability and efficacy of the extract are insufficient
Solution Approach 1:
The extraction process is divided into multiple sequential steps: initial extraction with organic solvent, filtration to remove impurities, concentration of the filtrate, and final drying to obtain the extract. This segmentation allows each step to be optimized independently, improving overall bioavailability while maintaining manageable process complexity
Solution Approach 2:
The extraction process maintains continuous useful action by immediately proceeding from extraction to filtration, then to concentration, and finally to drying without interrupting the flow of the extract. This continuous process prevents degradation of bioactive compounds and maximizes efficacy while streamlining the overall procedure
2Adaptability or versatility
If multiple bioactive compounds are included in the composition, then the therapeutic potential is enhanced, but the manufacturing precision requirements increase
Solution Approach 1:
The method establishes specific parameter ranges for each bioactive compound (withaferin A: 0.1-5%, withaferin B: 0.1-5%, withanone: 0.1-5%, withanolide A: 1-10%, withanolide B: 1-10%, withanoside IV: 1-10%, withanoside V: 1-10%, withanoside VI: 1-10%) to ensure consistent therapeutic potential while simplifying manufacturing quality control through defined specifications
Solution Approach 2:
The invention creates a composite extract containing multiple bioactive compounds from Withania somnifera that work synergistically. By standardizing the composition to include specific ranges of these compounds rather than isolating single constituents, the method enhances therapeutic potential while maintaining manageable manufacturing precision through composite standardization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel composition enhances the bioavailability and efficacy of Withania somnifera, offering improved stress management, energy levels, and overall health benefits, as demonstrated by increased withanolide content and enhanced dissolution profiles.
Implementation Method 1
extracting the dry powder obtained in step (b) with an aqueous alcohol solvent followed by filtration to obtain the supernatant and residue
Implementation Method 2
extracting the dry powder obtained in step (b) with an aqueous alcohol solvent
Implementation Method 3
subjecting the supernatant obtained in step (c) to distillation to obtain the crude extract
Implementation Method 4
subjecting the residue obtained in step (c) to hot water extraction followed by filtration and collection of the supernatant
Implementation Method 5
subjecting the residue obtained in step (c) to hot water extraction
Data Source
AI summary
Provided is a Withania somnifera extract composition contains at least one of withaferin A, withanoside IV, withanoside V, withanoside VI, withanolide A, withanolide B, anaferine, anahygrine, 12-deoxywithastromonolide, sitoindoside X, sitoindoside IX, cuscohygrine, isopelletierine, bracteosin A, bracteosin B, or bracteosin C, or a salt or solvate of any one thereof. Related compositions, methods, and processes are also provided.