Wound Composition Amino Acid Ratios Metabolic Constraints
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Solution Overview
Problem
Existing wound treatments, such as those containing hyaluronic acid or high fatty acid content, are not optimal for promoting wound healing, particularly in chronic and ischemic wounds with reduced blood supply, and may not be suitable for patients with conditions like cachexia or phenylketonuria.
Innovation Solution
A composition comprising specific ratios of proteinogenic amino acids (glycine, proline, and branched amino acids), metabolizable components (glycerol and carbohydrates), and lipids, along with optional excipients, is formulated to enhance wound healing by promoting the proliferative phase and reducing scarring, suitable for topical application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hyaluronic acid is used as an essential component in wound treatments, then wound healing is promoted, but it is not suitable for patients with certain metabolic conditions like cachexia or phenylketonuria
Solution Approach 1:
The patent removes hyaluronic acid from the composition to make it suitable for patients with metabolic conditions. The composition focuses on essential amino acids (glycine, proline, and branched-chain amino acids) that can be metabolized without the metabolic constraints associated with hyaluronic acid, thereby extracting the problematic component while retaining wound healing benefits.
Solution Approach 2:
The patent changes the compositional parameters by specifying precise ranges of amino acids (15-65 wt% glycine, 15-65 wt% proline, 20-70 wt% accumulated branched proteinogenic amino acids) instead of using hyaluronic acid. This parameter change allows the composition to be metabolically compatible with patients having restricted metabolic pathways.
2Reliability
If high content of fatty acids is used in wound compositions, then wound healing is supported, but the composition becomes disadvantageous due to excessive fat content
Solution Approach 1:
The patent changes the compositional parameters by limiting fatty acid content to a moderate range (5-15 wt%) rather than using high concentrations. This parameter adjustment maintains the beneficial effects of lipid components for wound healing while avoiding the disadvantages of excessive fat content that could impede healing or cause other complications.
3Reliability
If amino acids are provided directly to the wound, then tissue regeneration is promoted, but the amino acids are prone to oxidative phosphorylation which negatively affects the supporting effect over time
Solution Approach 1:
The patent provides amino acids in a continuous supply format through topical application of the composition. By maintaining constant presence of amino acids at the wound site via repeated applications, the composition ensures continuous support for tissue regeneration without interruption from oxidative phosphorylation cycles, effectively extending the duration of beneficial action.
Data Source
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AI summary
The present invention relates to a composition, preferably for treating a wound, comprising (i) a proteinogenic amino acids component comprising 15 to 65 wt.% of glycine, 15 to 65°wt.% of proline, and 20 to 70 wt.% of accumulated branched proteinogenic amino acids based on the total weight of the proteinogenic amino acids component (i), (ii) a metabolizable component selected from glycerol and a carbohydrate selected from pentoses and hexoses, (iii) a lipid component, (iv) optionally excipients and (v) water. The invention further relates to the present composition for topical administration and to the present composition for use in wound treatment.